多烯磷脂酰胆碱联合阿维A治疗寻常型银屑病的临床研究  

Clinical research of polyene phosphatidylcholine combined avermectin A method for treating psoriasis vulgaris

作　　者：陈蕾[1] 李芳谷[1] 马萍萍[1] 李定[1] 

机构地区：[1]广东医学院附属医院皮肤性病科,广东湛江524001

出　　处：《中国医药科学》2016年第11期88-90,共3页China Medicine And Pharmacy

摘　　要：目的研究多烯磷脂酰胆碱联合阿维A治疗寻常型银屑病的疗效及副反应。方法将60例于2014年12月-2015年12月我院皮肤性病科住院治疗并确诊为寻常型银屑病患者随机分为治疗组及对照组,每组各30例,治疗组予多烯磷脂酰胆碱注射液及阿维A胶囊联合治疗,对照组予阿维A胶囊治疗,4周为1个疗程,疗程结束后观察疗效及不良反应。结果疗程结束后痊愈率治疗组为50.0%,对照组为20.0%;总有效率治疗组为93.3%,对照组为73.3%;差异均有统计学意义（P〈0.05）;治疗后,两组患者空腹血清ALT、AST对比差异有统计学意义（P〈0.01）。结论多烯磷脂酰胆碱联合阿维A较单用阿维A治疗寻常型银屑病疗效更好,致肝损害的副反应更小。Objective To research the efficacy and adverse reactions with the method of polyene phosphatidylcholine combined avermectin A for treating psoriasis vulgaris. Methods 60 hospitalized diagnosed patients with psoriasis vulgaris in our department from December 2014 to December 2015 were randomly divided into the treatment group and the control group（30 in each group）. Patients in the treatment group were treated with method of polyene phosphatidylcholine combined avermectin A. Patients in the control group were treated with method of avermectin A capsule. The treatment lasted for four weeks. Efficacy and adverse reactions were observed after the course of treatment. Results The cure rate of the treatment group was 50.0%, and the control group was 20.0%. The total effective rate of the treatment group was 93.3%, and the control group was 73.3%. The differences of the above indexes were statistically significant（P〈0.05）. After treatment, the Comparative differences of fasting serum ALT and AST of the two groups had statistical significance（P 〈0.01）. Conclusion The treatment effect of polyene phosphatidylcholine combined avermectin A method for treating psoriasis vulgaris was better than single avermectin A treatment, and also less side effects of liver damage.

关 键 词：多烯磷脂酰胆碱 阿维A 寻常型银屑病 ALT AST 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]