不同药物含量血管支架对内皮化进程的影响  

Effect of various drug-content coated stents during endothelialization in vivo

作　　者：刘恒全 潘长江[2] 张文凯 刘涛[2] 

机构地区：[1]深圳迈德科技有限公司,广东深圳518103 [2]淮阴工学院江苏省介入医疗器械重点实验室,江苏淮安223003

出　　处：《中国介入影像与治疗学》2016年第8期490-494,共5页Chinese Journal of Interventional Imaging and Therapy

基　　金：国家自然科学基金(31470926);深圳市科创委专项基金(CXZZ20140401143609670)

摘　　要：目的 探讨不同剂量的药物支架在抑制血管再狭窄过程中对内皮化进程的影响。方法 采用超声雾化法在L605金属支架表面制备不同雷帕霉素含量的药物支架,将其分别植入新西兰大白兔腹主动脉,第1、4、12周后通过扫描电镜、组织切片分析药物含量对血管支架内皮化程度的影响。结果 不同药物含量的血管支架在各时间点血管内腔通畅、光滑、无血栓形成,但随着药物含量的升高,内皮化程度会延迟。结论 雷帕霉素含量80~110μg/cm时药物支架对血管功能恢复及防止再狭窄作用显著。Objective To explore the effect of various drug-content coated stents during endothelialization in vivo. Meth- ods The various contents of Rapamycin coated L605 stents were prepared by ultrasonic nebulization method, and the stents were implanted into abdominal aorta of New Zealand rabbits. The effect at 1st , 4th , 12th weeks of various drug-con- tent stents on endothelialization process was investigated by scanning electron microscopy and tissue section. Results In- travascular lumen was smooth, and no any thrombosis was observed to all stents in each period, but the endothelialization was delayed while the drug concentrate rose. Conclusion It is satisfactory drug concentrate of 80--1 10μg/cm to vessel re- modeling and prevent restenosis.

关 键 词：支架 冠状动脉再狭窄 药物含量 内皮化 

分 类 号：R541.4[医药卫生—心血管疾病]