Wnt/β-catenin信号通路的激活及调控在不同中医证型乳腺癌中的意义及机制  

The significance and mechanism of activation and regulation of wnt/β-catenin signal pathway in breast cancers with different TCM syndromes

作　　者：宫国良 陈静宁 刘晓雨 张元鑫 林腾[3] 

机构地区：[1]汕头潮南民生医院病理科,广东汕头515044 [2]汕头市金平区妇幼保健院妇产科,广东汕头515044 [3]汕头大学医学院第一附属医院

出　　处：《中国实验诊断学》2016年第7期1076-1079,共4页Chinese Journal of Laboratory Diagnosis

基　　金：广东省中医药局建设中医药强省科研资助项目粤中医〔2014〕25号

摘　　要：目的探讨β-catenin、Slug、P-GSK3β在不同中医证型乳腺癌中的表达,进而分析不同中医证型乳腺癌Wnt/β-catenin信号通路激活及调控的意义及机制。方法对102例乳腺癌患者进行术前中医辨证分型,术后行病理常规检查,并进行β-catenin、Slug、P-GSK3β免疫组织化学染色。结果 102例乳腺癌中肝郁痰凝型47例(46.08%),冲任失调型36例(35.29%),正虚毒炽型19例(18.63%);不同中医证型组β-catenin、Slug、P-GSK3β的表达存在差异性,组间比较具有统计学意义。结论 Wnt/β-catenin信号通路的激活在不同中医证型乳腺癌中存在差异,且该差异与Slug、P-GSK3β的调控相关。Objective To investigate the expression ofβ-catenin,Slug and P-GSK3βin breast cancers with different Traditional Chinese Medicine（TCM）syndromes,and further anlyze the significance and mechanism of activation and regulation of wnt/β-catenin signal pathway in breast cancers with different TCM syndromes.Methods Preoperative TCM syndrome differentiation was carried out on 102 patients with breast cancer,.Routine pathological examination was performed postoperatively,and immunohistochemical staining was conducted forβ-catenin,slug and P-GSK3β.Results Among the 102 patients with breast cancer,47patients（46.08%）had liver-qi stagnation and phlegm stagnation type,36（35.29%）had Chong and Ren disorders,and 19（18.63%）had is the deficiency of heat toxin type.Moreover,the expression ofβ-catenin,slug and P-GSK3βamong different TCM syndrome groups demonstrated differeces,which showed statistical significance.Conclusion The activation of wnt/β-catenin signal pathway has different effects on breast cancers with different TCM syndromes,which are associated with the regulation ofβ-catenin,slug and P-GSK3β.

关 键 词：乳腺癌 中医证型 免疫组织化学 

分 类 号：R273[医药卫生—中西医结合]