cTnI与BNP对AECOPD伴呼吸衰竭患者预后评估的价值  

Values of Prognostic Evaluations of cTnI and BNP on Patients with AECOPD Combined with Respiratory Failure

作　　者：赵华栋 朱勇 龚晓男 李洁萍 

机构地区：[1]锦州医科大学附属第三医院,辽宁锦州121000

出　　处：《辽宁医学院学报》2016年第4期71-73,共3页Journal of Liaoning Medical University (LNMU) Bimonthly

摘　　要：目的探讨肌钙蛋白-I(c Tn I)与脑钠肽(BNP)水平与慢性阻塞性肺疾病急性加重期(AECOPD)伴呼吸衰竭患者预后的关系。方法回顾性分析我科收治的68例AECOPD伴呼吸衰竭患者临床资料,根据预后分为好转组和死亡组,比较两组Tn I、BNP、WBC、乳酸(Lac)水平及APACHEⅡ评分的差异,分析c Tn I、BNP与APACHEⅡ评分、WBC及Lac之间的相关性。结果死亡组的c Tn I、BNP、APACHEⅡ评分、Lac水平均高于好转组,差异有统计学意义(P<0.05);c Tn I、BNP与APACHEⅡ评分呈正相关(r分别=0.777,0.840,P均<0.05),c Tn I、BNP与Lac呈正相关,差异均具有统计学意义(r分别=0.744,0.705,P均<0.05)。结论 c Tn I、BNP可以作为常规临床检测指标来判断AECOPD伴呼吸衰竭患者的预后。Objective To discuss the relationship between the levels of cardiac troponin-I （cTnI） or brain natriuretic peptide （BNP） and prognosis in patients with AECOPD combined with respiratory failure. Methods The clinical data of 68 cases of AECOPD combined with respiratory failure in our department were given retrospective analyses. The patients were divided into the recovery group and the death group according to their prognosis. The level of cTnI, BNP, WBC, Lactate （Lac） and the differences in APACHE II scores of the two groups were compared. The correlations between cTnI, BNP and APACHE lI scores, WBC as well as Lac were ana- lyzed. Results The cTnI, BNP, APACHE I1 scores and Lac level of the death group were all higher than those of the recovery group, and the differences were statistically significant （P〈0.05） ; cTnI and BNP were positively related to APACHE 11 scores （ r = 0. 777 and 0. 840 respectively, P mean 〈0. 05） ; cTnI and BNP were positively related to Lac, and the differences were statistically significant （ r = 0. 744 and 0. 705 respectively, P mean 〈0.05 ）. Conclusion cTnI and BNP can be used as a routine clinical detec- tion index to judge the prognosis of the patients with AECOPD combined with respiratory failure.

关 键 词：肌钙蛋白-I 脑钠肽 急性生理与慢性健康状况Ⅱ评分 乳酸 慢性阻塞性肺疾病急性加重期 

分 类 号：R563.8[医药卫生—呼吸系统]