48例脑心双死亡器官捐献肾移植的临床分析  

Clinical analysis on 48 cases of kidney transplantation from brain and cardiac death donors

作　　者：洪汉利[1] 陈统清[1] 林敏娃[1] 谢碧琴[1] 孔耀中[1] 叶佩仪[1] 誉铁鸥[2] 张海滨[3] 刘建华[3] 陈勇[3] 

机构地区：[1]佛山市第一人民医院肾内科,528000 [2]佛山市第一人民医院ICU,528000 [3]佛山市第一人民医院泌尿外科,528000

出　　处：《中华肾脏病杂志》2016年第7期502-506,共5页Chinese Journal of Nephrology

基　　金：佛山市卫生局医学科研课题（2014035）

摘　　要：目的：观察脑心双死亡器官捐献（DBCD）肾移植短期临床疗效，评估扩大供体器官来源可行性。方法对2011年9月至2015年2月期间在本院进行DBCD肾移植并完成12个月随访的48例患者的临床资料进行回顾性总结。观察肾移植术后受者1周、1个月、3个月、6个月、1年肾功能、排斥反应及并发症等，统计学分析肾移植术后受者生存率、移植肾生存率、肾功能延迟恢复（DGF）发生率及DGF对受者及移植肾生存率影响。结果48例受者1、3、6、12个月生存率分别为100.0%、100.0%、97.9%、95.8%，移植肾存活率分别为95.8%、95.8%、93.8%、91.7%。DGF有8例，发生率为17.0%，DGF组与无DGF组受者生存率及移植肾存活比较，差异无统计学意义（P值分别为0.524、0.362）。结论 DBCD肾移植短期效果理想。在我国尚无脑死亡相关法律规定的环境下，DBCD肾移植是解决我国器官短缺的重要手段，有助于扩大供肾来源。Objective To observe the short？term clinical outcomes of kidney transplantation from brain and cardiac death donors （DBCD） and assess its feasibility to expand organ donor pool. Methods A retrospective analysis was performed on 48 cases of kidney transplantation from DBCD. The transplant recipients had finished 12？month follow？up in the First People＆#39;s Hospital of Foshan from September 2011 to February 2015, with their renal function, rejection reaction and complications at 1 week, 1 month, 3 months, 6 months and 12 months after renal transplantation being collected. Survival rates of transplant recipients and transplant kidneys, incidence of delayed graft function （DGF） and its influence for recipients and graft survival were analyzed by statistics. Results In the 48 cases, the survival rates of recipients at 1, 3, 6 and 12 months after transplantation were 100.0%, 100.0%, 97.9%, 95.8%, and the survival rates of transplanted kidneys were 95.8%, 95.8%, 93.8%, 91.7%, respectively. DGF occurred in 8 of 48 （17.0%）, but the occurrence of DGF did not adversely influence patient＆#39;s survival （P=0.524） or graft survival （P=0.362）. Conclusions The short？term clinical outcomes of kidney transplantation from DBCD are ideal. As the legislation of donation after brain death （DBD） has not been ratified in China, the kidney transplantation from DBCD could be an 〈br〉 important way to solve the shortage of organs, and increase the number of kidneys available for transplantation.

关 键 词：肾移植 预后 脑心脏双死亡器官捐献 

分 类 号：R699.2[医药卫生—泌尿科学]