肺表面活性物质联合鼻塞式持续气道正压通气治疗新生儿呼吸窘迫综合征疗效观察  

Effect of pulmonary surfactant combined with nasal continuous positive airway pressure in the treatment of neonatal respiratory distress syndrome

作　　者：谢怀珍[1] 董传莉[1] 张兰[1] 宫芬[1] 

机构地区：[1]蚌埠医学院第二附属医院儿科,安徽蚌埠233040

出　　处：《蚌埠医学院学报》2016年第6期750-752,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨肺表面活性物质(PS)联合鼻塞式持续气道正压通气(n CPAP)治疗新生儿呼吸窘迫综合征(NRDS)的疗效。方法:对36例NRDS患儿应用PS联合n CPAP治疗,观察患儿的临床表现及血气指标在治疗前后的变化。结果:36例患儿应用PS联合n CPAP治疗后,33例治疗4 h左右青紫、气促、呻吟、三凹征均明显缓解或消失,血气分析显示动脉血氧分压明显上升,动脉血二氧化碳分压明显下降,酸中毒有不同程度的纠正(P<0.01),治疗成功率达91.67%;3例患儿治疗无效转为机械通气。所有患儿均无慢性肺疾病发生。结论:PS联合n CPAP治疗NRDS效果良好。该技术系无创通气,操作简便快捷,能阻止NRDS的进展,有效地避免使用机械通气,降低慢性肺疾病的发生。Objective： To investigated the effects of pulmonary surfactant（ PS） combined with nasal continuous positive airway pressure（ NCPAP） in the treatment of neonatal respiratory distress syndrome（ NRDS）. Methods： Thirty-six cases with NRDS were treated with NCPAP combined with PS. The changes of clinical manifestation and blood gas index in 36 patients were observed before and after treatment. Results： After 4 hours of treatment of the 36 NRDS cases treated with NCPAP combined with PS,the cyanosis,shortness of breath,groan and three depressions sign significantly relieved or disappeared,the blood gas analysis showed that the Pa O2 increased obviously,the Pa CO2 decreased significantly and the acidosis were corrected in 33 cases. The success rate was 91. 67%. The other 3 cases with invalid treatment were changed to the mechanical ventilation treatment. No chronic lung disease occurred in all patients. Conclusions： The clinical effect of NRDS treated with NCPAP combined with PS is good. The treatment method is noninvasive ventilation,simple and quick,which can prevent the development of NRDS,avoid the mechanical ventilation use and decrease the occurrence of chronic lung disease.

关 键 词：新生儿呼吸窘迫综合征 肺表面活性物质 鼻塞式持续气道正压通气 

分 类 号：R722.1[医药卫生—儿科]