α-硫辛酸对单纯性肥胖患者氧化应激及内皮功能的影响  

Effects of α-lipoic acid on oxidative stress and endothelial function in simple obesity

作　　者：涂传发 王丽君[1] 牟晓月[1] 

机构地区：[1]浙江台州市第一人民医院内分沁科,浙江台州318000

出　　处：《中国生化药物杂志》2016年第5期60-62,65,共4页Chinese Journal of Biochemical Pharmaceutics

基　　金：浙江台州市黄岩区科技局计划项目(2013059-28)

摘　　要：目的探讨α-硫辛酸对单纯性肥胖患者氧化应激及内皮功能的影响。方法收集单纯性肥胖志愿者60例,根据随机对照表分为对照组和试验组,其中试验组30例,对照组30例,2组患者采用常规治疗以及对症治疗,试验组给予α-硫辛酸针0.6 g+0.9%氯化钠针250 m L静脉滴注,每天1次;对照组给予0.9%氯化钠针250 m L静滴,每天1次。2组均以14 d为1个疗程,共治疗1个疗程。治疗结束后对比分析2组氧化物、抗氧化物、血管内皮功能以及胰岛素抵抗。结果与对照组相比,试验组体质量、血糖以及血脂水平均较低(P<0.05),活性氧(ROS)、丙二醛(MDA),谷胱甘肽(GSH)水平较低(P<0.05),谷胱甘肽过氧化物酶(GSH-Px)水平较高(P<0.05),内皮依赖性血管舒张功能(EDV)水平较高(P<0.05),内皮素-1(ET-1)水平较低(P<0.05)。胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(ISI)水平较低(P<0.05)。结论α-硫辛酸对单纯性肥胖患者临床疗效显著,能够改善氧化应激以及内皮功能,降低体质量、血糖以及血脂,抑制胰岛素抵抗。Objective To investigate the effects of α-lipoic acid on oxidative stress and endothelial function in patients with simple obesity. Methods A total of 60 volunteers with simple obesity were collected and randomly divided into control group and experimental group with 30 cases in each group. The two groups were treated by routine treatment and symptomatic treatment, patients in the experimental group were treated by α-lipoic acid 0. 6 g ＋ 0. 9% sodium chloride injection 250 mL intravenous drip, once daily; patients in the control group were treated by 0.9% sodium chloride injection 250 mL intravenous drip , once daily. Two groups received treatment for one course of 14 days. After treatment , the oxide, antioxidants, vascular endothelial function and insulin resistance of the two groups were compared. Results Compared with control group after treatment, the weight, blood glucose and blood lipid levels in experimental group were lower （ P 〈 0.05 ）, ROS, MDA, GSH in experimental group were lower （ P 〈 0. 05 ）, GSH-Px level in experimental group was higher （ P 〈 0.05 ）, EDV level in experimental group was higher （ P 〈 0. 05 ）, ET -1 level in experimental group was lower （P 〈 0.05 ）, HOMA - IR and ISI levels in experimental group were lower （ P 〈 0. 05 ）. Conclusion α-lipoic acid has an obvious efficacy in the treatment of patients with simple obesity , which could improve the oxidative stress and endothelial function, reduce weight, blood glucose and blood lipid and inhibit insulin resistance.

关 键 词：Α-硫辛酸 单纯性肥胖 氧化应激 内皮功能 

分 类 号：R723.14[医药卫生—儿科]