奥曲肽配合乳果糖灌肠对急性胰腺炎患者体内炎性因子及肠黏膜屏障水平的作用  

Effect of octreotide combined with lactulose enema on inflammatory cytokines and intestinal mucosal barrier in acute pancreatitis

作　　者：赵岳[1] 李永祥[1] 凌铿[1] 钱雅琴[1] 张晓燕[1] 

机构地区：[1]嘉兴市妇幼保健院检验科,浙江嘉兴314000

出　　处：《中国生化药物杂志》2016年第5期110-113,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的评价急性胰腺炎给予奥曲肽配合乳果糖灌肠的疗效,以及该疗法对体内炎性因子及肠黏膜屏障水平的作用。方法将嘉兴市妇幼保健院确诊并收治的106例急性胰腺炎患者随机分为研究组和对照组各53例。对照组实施常规治疗及奥曲肽静脉滴注治疗,研究组在对照组基础上加用乳果糖灌肠治疗。对比2组疗效、临床起效时间、治疗前后炎症因子水平及肠黏膜屏障功能水平。结果研究组总有效率为92.45%,显著优于对照组的77.36%(P<0.05)。研究组腹痛、腹胀缓解时间、血清淀粉酶水平恢复正常时间显著快于对照组(P<0.05),禁食时间显著少于对照组(P<0.05)。2组治疗前肿瘤坏死因子α、白细胞介素6及超敏C反应蛋白水平无显著差异,2组治疗后上述指标水平与治疗前相比均显著改善(P<0.05),研究组改善幅度显著大于对照组(P<0.05)。2组治疗前血清降钙素原及血浆D-乳酸水平无显著差异,治疗后均显著改善(P<0.05),研究组改善幅度显著大于对照组(P<0.05)。结论急性胰腺炎给予奥曲肽配合乳果糖灌肠疗效确切,同时可显著遏制体内炎性反应,使肠黏膜屏障功能得到保护。Objective To evaluate the efficacy of octreotide combined with lactulose enema and the effect of the therapy on inflammatory factors and intestinal mucosal barrier in acute pancreatitis. Methods 106 patients with acute pancreatitis were randomly divided into study group and control group, 53 patients in each group. The control group were treated with conventional therapy and intravenous drip of octreotide, and the study group were treated with the the lactulose enema on the basis of control group. The efficacy, clinical onset time, the levels of inflammatory factors and intestinal mucosal barrier function were compared between the two groups before and after treatment. Results The total effective rate of the study group was 92. 45% , which was significantly higher than 77.36% of the control group （ P 〈 0. 05 ）. The abdominal pain time, time of abdominal distension remission, and the time of serum amylase level returning to normal in the study group were significantly higher than those in the control group （ P 〈 0.05 ）, and the fasting time was significantly shorter than that in the control group （ P 〈 0. 05 ）. There was no significant difference in tumor necrosis factor alpha, interleukin-6 and high sensitive C reaction protein levels between two groups pre-treatment, but the above indicators post-treatment in two groups significantly improved compared with pre-treatment（ P 〈0. 05 ）, and the above indicators in study group were better than those in control group （P 〈 0. 05）. There was no significant difference in serum calcitonin peptide and plasma D-lactate levels pre-treatment between two groups, but after treatment were significantly improved （P 〈 0. 05 ）, the study group improved significantly better than the control group （ P 〈 0. 05 ）. Conclusion The efficacy of octreotide combined with lactulose enema is effective for acute pancreatitis, and it could also significantly restrain the inflammatory reaction in the body, which could protect the function of intestinal mu

关 键 词：急性胰腺炎 奥曲肽 乳果糖 炎性因子 肠黏膜屏障 

分 类 号：R657.51[医药卫生—外科学]