阿尔茨海默病患者松果体MRI研究  

The pineal gland MRI study in Alzheimer's patients

作　　者：邓玲[1] 钱学华[1] 郭轶[2] 徐玉玉[1] 吕发金[2] 

机构地区：[1]重庆医科大学解剖学教研室、法医学与生物医学信息研究室 [2]重庆医科大学附属第一医院放射科,重庆400016

出　　处：《中国临床解剖学杂志》2016年第4期378-382,共5页Chinese Journal of Clinical Anatomy

摘　　要：目的观察阿尔茨海默病(Alzheimer’s disease,AD)发病进程中松果体的MRI形态学改变。方法依据AD发病进程,分别采集NC组24例、MCI组18例、轻度AD组16例、中-重度AD组20例受试者大脑MRI扫描图像,测量松果体矢径、横径、高、体积,并分析组间各测量值变化趋势。结果松果体标化高MCI期、轻度AD期较NC组增大(P<0.05),中-重度AD期标化高较MCI期、轻度AD缩小(P<0.05);松果体标化矢径、标化横径、标化体积MCI期、轻度AD、中-重度AD与NC组比无明显变化(P>0.05),但中-重度AD较MCI期组缩小(P<0.05)。结论在AD发病进程中松果体高先增大再萎缩,松果体高对MCI期、轻度AD患者的诊断有较大价值。Objective To observe morphological changes of pineal gland in the process of Alzheimer＇ s disease（AD） by MRI. Methods According to the process of AD, brain MRI images of 24 cases, 18 cases, 16 cases and 20 cases from the normal control group, MCI group, mild AD group and moderate- severe AD group, respectively. Length, width, height and volume of the pineal gland had been measured, the change trend of the measurement between each group was then analyzed. Results The standardized height of pineal gland had an increase in the MCI and mild AD compared with NC group（P〈0.05）and had a reduction in the moderate- severe AD compared with the MCI and mild AD（P〈0.05）; The standardized length, width and volume of pineal gland had no significant change in the MCI, mild AD and moderate- severe AD compared with NC group（P〉0.05）,but had a reduction in the moderate- severe AD compared with MCI（P〈0.05）. Conclusion The height of pineal gland has a growth tendency at the incipient stage of the process of AD, and then will shrink. Measurement the height of pineal gland by MRI was helpful in the diagnosis of MCI and mild AD patients.

关 键 词：阿尔茨海默病 松果体 MRI 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学]