实验兔单侧输尿管部分梗阻后基础状态下肾小球滤过功能的变化特点  

Variations of basic glomerular filtration function in experimental rabbits with partial unilateral ureteral obstruction

作　　者：汪长银[1] 杨奇盛[2] 高纯[3] 买买提[3] 李顺[3] 江凌龙[1] 涂小朋[2] 

机构地区：[1]武汉大学中南医院核医学科,430071 [2]武汉大学中南医院急救中心外科,430071 [3]武汉大学医学部临床医学系,2010级430072

出　　处：《实用医学杂志》2016年第14期2283-2287,共5页The Journal of Practical Medicine

基　　金：湖北省自然科学基金资助项目(编号:2011CHB035)

摘　　要：目的:观察兔输尿管部分梗阻后基础肾功能的变化特点。方法:30只成年健康日本大耳白兔分为对照组6只和梗阻组24只。采用套管法制作右输尿管部分梗阻模型,据梗阻时间均分为4组,即梗阻7、14、28和56 d组。以肾动态显像测量各组肾小球滤过率(GFR),分析其肾功能与梗阻时间的关系,并观察健侧肾脏功能的变化。结果:(1)对照组双肾GFR比较差异无统计学意义(t=-0.145,P=0.894);梗阻组右肾GFR均低于左肾(P<0.05)。(2)右肾GFR比较,梗阻7 d组与对照组差异具有统计学意义(t=5.066,P=0.001),梗阻7、14、28、56 d组间差异无统计学意义(P>0.05)。(3)左肾GFR比较,对照组、梗阻7、14、28、56 d组间差异无统计学意义(P>0.05)。结论 :单侧输尿管部分梗阻后,梗阻肾脏的功能呈现先期大幅度下降之后趋于稳定的变化特征,健侧肾脏的基础肾功能未见代偿。Objective To investigate the variations of glomerular function in rabbits with partial unilateral ureteral obstruction（PUUO）. Methods Thirty healty adult Japanese White Rabbits were randomly divided into the control group（6 rabbits） and the obstruction group（24 rabbits）. The right PUUO model was established according to Cheng′s method. According to the PUUO duration, they were eaqually divided into four subgroups ：the 7 day PUUO group, the 14 d PUUO group, the 28 d PUUO group and the 56 d PUUO group. The dynamic renal imaging was performed on all rabbits, and the glomerular filtration rate（GFR） was also calculated. The correlation between the renal function and PUUO duration was analyzed, and functional variations in the healthy kidneys were observed. Results（1）To the control group, no significant difference in the renal function was found between the left and the right kidneys（t =-0.145, P = 0.894）. However, to the PUUO group, the right renal GFRs were significantly lower than the left renal GFRs（P〈 0.05）.（2） To the right renal GFR, significant difference was observed between the 7 day PUUO group and the control group（t = 5.066, P = 0.001）,but not among the 7 day PUUO group, the 14 day PUUO group, the 28 day and the 56 day PUUO group（P 〉0.05）,（3）No significant differences were found in the left renal GFRs among the five groups. Conclusions The function of PUUO kidneys is characterized by an obvious decrease in the early stage, followed with a steady state.The basic function of the opposite healthy kidney does not present the compensation phenomenon.

关 键 词：输尿管梗阻 肾小球滤过率 放射性核素显像 兔 

分 类 号：R699.4[医药卫生—泌尿科学]