树突状细胞在急性肾损伤中的研究进展  

Progress of dendritic cells in acute kidney injury

作　　者：梁怡然 张冰莹[1] 吴声[1] 丁小强[1] 方艺[1] 

机构地区：[1]复旦大学附属中山医院肾内科,上海200032

出　　处：《中国临床医学》2016年第3期379-382,共4页Chinese Journal of Clinical Medicine

基　　金：国家自然科学基金(81200557);上海市科学技术委员会科研计划项目(14DZ2260200)~~

摘　　要：树突状细胞(dendritic cells,DC)是连接固有免疫和适应性免疫的桥梁,在免疫反应中发挥重要的抗原提呈作用。急性肾损伤(acute kidney injury,AKI)是各种原因导致的急性肾脏实质损伤。肾脏极易发生缺血性损伤,而免疫炎症反应是急性缺血性肾损伤发生发展的重要机制,其中树突状细胞和肾小管上皮细胞间的相互作用有望成为治疗肾损伤和延缓其病程的新靶点。Dendritic cells（DC）serve as a bridge between innate immune response and adaptive immune response by playing a role as important antigen presenting cells.Acute kidney Injury（AKI）results in acute renal parenchymal injury caused by multiple reasons.The kidney is very prone to ischemic injury,and the immune inflammatory response is an important mechanism in the development of acute ischemic renal injury,in which the interaction between dendritic cells and renal tubular epithelial cells is expected to be the new target to treat renal damage and delay the course of the disease.

关 键 词：急性肾损伤 树突状细胞 缺血性肾损伤 免疫炎性反应 

分 类 号：R692.5[医药卫生—泌尿科学]