肠黏膜屏障老化研究进展  

Research Advances in Aging of Intestinal Mucosal Barrier

作　　者：卢萌[1] 庄艳[1] 郑松柏[1] 

机构地区：[1]复旦大学附属华东医院老年医学科,中国上海200040

出　　处：《国际老年医学杂志》2016年第4期180-185,F0003,共7页International Journal of Geriatrics

基　　金：卫生行业科研专项项目（201302008）

摘　　要：肠黏膜屏障主要由微生态屏障、化学屏障、机械屏障、免疫屏障等组成，稳定而完整的肠黏膜屏障才能阻止肠腔中的病原体和有害物质进入机体内环境，以维持机体内环境的稳定。老年人常处于低度炎症状态，某些肠道疾病和SIRS、MODS高发，可能与其肠黏膜屏障结构和功能退化有关。本文对肠黏膜屏障的老化研究进展做一综述。The intestinal mucosal barrier is mainly composed of the microbiota barrier, the chemical barrier, the mechanical bar- rier and the immune barrier. The integrety of the barrier essentially prevents the potentially microorganisms and harmful compounds in- to the body and to keeps the stability of the internal environment. The high incidence of some intestinal diseases, such as SIRS and MODS in the elderly who are often in a state of low - grade inflammation, may be related to the degeneration of the structure and the function of intestinal mucosal barrier. This paper reviews the current researches in the aging of intestinal mucosal barrier.

关 键 词：肠黏膜屏障 微生态 免疫衰老 老化 

分 类 号：R333.3[医药卫生—人体生理学]