狗牙花总生物碱的身体依赖性实验研究  

Experimental study on physical dependence of total Ervatamia yunnansis alkaloid

作　　者：栗志远[1,2] 张晓冬[2] 王新红[1] 周铎[1] 

机构地区：[1]解放军22医院,青海格尔木816099 [2]第二军医大学新药评价中心,上海200433

出　　处：《药学实践杂志》2016年第4期327-329,共3页Journal of Pharmaceutical Practice

基　　金：青海省科技厅应用基础研究项目(2014-ZJ-753);国家自然科学基金资助项目(81171260)

摘　　要：目的评价狗牙花总生物碱的身体依赖性潜力。方法采用小鼠催促戒断和大鼠自然戒断模型对狗牙花总生物碱进行身体依赖性实验。结果在小鼠催促实验中,给予狗牙花总生物碱低剂量(140mg/kg)、高剂量(430mg/kg),连续注射7d,而后经纳洛酮激发,实验小鼠未出现明显的戒断症状、跳跃次数增加和体重下降现象。在大鼠自然戒断实验中,给予狗牙花总生物碱低剂量(210mg/kg)、高剂量(775mg/kg),连续注射30d,停药后未见大鼠出现戒断反应和体重下降现象。结论狗牙花总生物碱无身体依赖性。Objective To evaluate the physical dependence of total Ervataznia yunnansis alkaloid. Methods The physi- cal dependence of total Ervatamia yunnansis alkaloid was observed by jump test in mice and spontaneous withdrawal test in rats. Results In the jump test, after injecting total Ervatamia yunnansis alkaloid （total dosage of 140 and 430 mg/kg） for 7 days continuously, the mice didn＇t show any withdrawal symptom and the loss of body weight. In the spontaneous withdrawal test, two dosages of total Ervatarnia yunnansis alkaloid （total dosage of 210 and 775 mg/kg） were continuously given for 30 days. The withdrawal response and the loss of body weight were not found in rats after drug withdrawal. Conclusion Total Ervatamia yunnansis alkaloid showed no obvious withdrawal symptoms in mice and rats, which suggests that it has no physical dependence.

关 键 词：狗牙花总生物碱 身体依赖性 吗啡 

分 类 号：R965[医药卫生—药理学] R285[医药卫生—药学]