支气管哮喘儿童血清sFas、sFasL的临床意义  

Clinic significance of sFas/sFasL in serum of children with asthma

作　　者：冯金环[1] 王孟兰 张俊英 王晓健 

机构地区：[1]青大医学院附属青岛海慈医院儿科,山东青岛266033 [2]青大医学院附属青岛海慈医院血液透析室,山东青岛266033

出　　处：《中国儿童保健杂志》2016年第8期887-888,共2页Chinese Journal of Child Health Care

摘　　要：目的研究支气管哮喘儿童血清可溶性Fas受体和Fas配体(sFas/sFasL)的水平变化及临床意义。方法选取67例支气管哮喘儿童(哮喘组)及健康儿童40例(对照组),采用双抗体夹心(ABC-ELISA)法检测哮喘组及对照组血清sFas、sFasL水平,并进行比较。结果哮喘组血清sFas、sFasL水平分别为(91.89±21.25)、(1 080.37±306.59)ng/L均明显高于对照组的(29.58±7.26)、(496.70±47.60)ng/L,差异有统计学意义(P<0.01)。结论 sFas、sFasL可能参与了儿童支气管哮喘的发病过程。Objective To explore the clinic significance of sFas/sFasL in serum of children with asthma. Methods A total of 67 children with asthma （asthma group） and 40 healthy children （healthy control group） were selected, sFas, sFasL in their serums were detected by ABC-ELISA. Results Compared with healthy control group,the sFas and sFasL in serum of asthma group were elevated markedly（P〈0.01）. Conclusion The sFas,sFasL in children with asthma were higher than healthy children,sFas/ sFasL maybe take part in the pathological process of asthma.

关 键 词：儿童 哮喘 SFAS SFASL 凋亡 

分 类 号：R179[医药卫生—妇幼卫生保健]