坦索罗辛结合体外冲击波碎石术治疗输尿管壁段结石疗效评价  

Tamsulosin Combined with ESWL in Treating Ureterovesical Junction Stones

作　　者：刘春林[1] 渠渊[1] 张进生[1] 柴军[1] 刘宁[1] 吴宗山[1] 

机构地区：[1]首都医科大学附属复兴医院泌尿外科,北京100038

出　　处：《中国药业》2016年第14期38-40,共3页China Pharmaceuticals

摘　　要：目的探讨坦索罗辛辅助体外冲击波碎石术(ESWL)治疗输尿管壁段结石的临床效果。方法选取2012年3月至2015年8月医院泌尿外科采用ESWL治疗的输尿管壁段结石患者110例,根据术后治疗方法的不同分为试验组和对照组,各55例。对照组患者术后仅采用常规疗法,试验组患者采取常规疗法+坦索罗辛治疗,观察4周,比较两组患者的结石清除效果。结果第1次ESWL术后,试验组清石率为78.18%,显著高于对照组的56.36%(P<0.05);排石时间、肾绞痛发作次数、疼痛视觉模拟评分法(VAS)评分均显著低于对照组(P<0.05)。第2次ESWL术后,试验组清石率为96.36%,显著高于对照组的81.82%(P<0.05);排石时间、VAS评分均显著低于对照组(P<0.05)。两组患者的肾绞痛发作次数比较,差异无统计学意义(P>0.05)。结论坦索罗辛辅助ESWL治疗输尿管壁段结石可有效增加清石率、减轻患者的肾绞痛发作次数及疼痛程度,值得临床推广。Objective To investigate the clinical efficacy of tamsulosin assisted with extracorporeal shock wave lithotripsy（ ESWL） for the treatment of ureterovesical junction stones. Methods 110 cases of patients with ureterovesical junction stones treated by ESWL from March 2012 to August 2015 were selected and divided into the experimental group and the control group according to the treatment methods after ESWL,55 cases in each group. The control group only used conventional therapy,the experimental group took conventional therapy ＋ tamsulosin treatment. After 4 weeks of observation,the stone clearance efficacies between the two groups were compared. Results After the first ESWL,the stone clearance rate of the experimental group was 78. 18%,which was significantly higher than 56. 36% of the control group（ P〈0. 05）,and the time of removing urinary calculus,renal colic episodes,VAS score were significantly lower than the control group（ P〈0. 05）. After the second ESWL,the stone clearance rate of the experimental group was 96. 36%,which was significantly higher than 81. 82% of the control group（ P〈0. 05）,and the time of removing urinary calculus and VAS score were significantly lower than the control group（ P〈0. 05）. The renal colic episodes of the two groups had no statistically significant difference（ P〉0. 05）. Conclusion Tamsulosin assisted with ESWL in treating ureterovesical junction stones can effectively increase the stone clearance rate,reduce the frequency of renal colic and severity of pain,which is worthy of clinical promotion.

关 键 词：坦索罗辛 体外冲击波碎石术 输尿管壁段结石 

分 类 号：R969.4[医药卫生—药理学] R983[医药卫生—药学]