美金刚联合盐酸多奈哌齐治疗阿尔茨海默病疗效研究  

Memantine Combined with Hydrochloride Donepezil in Treating Alzheimer's Disease

作　　者：蒋志宏[1] 蔡鸣[1] 谷新医[1] 马强[1] 

机构地区：[1]大连大学附属中山医院神经内科,辽宁大连116001

出　　处：《中国药业》2016年第14期55-58,共4页China Pharmaceuticals

摘　　要：目的探讨美金刚联合盐酸多奈哌齐治疗阿尔茨海默病(AD)的疗效。方法选取医院2013年6月至2015年6月收治的AD患者98例,将其随机分为治疗组和对照组,各49例。对照组患者采用盐酸多奈哌齐治疗,治疗组患者在对照组治疗基础上加用美金刚治疗。比较两组患者的临床疗效、精神行为障碍、日常生活能力、不良反应等情况。结果治疗组总有效率为93.88%,显著高于对照组的79.59%(P<0.05);治疗后,两组痴呆病理行为评定量表(BEHAVE-AD)评分、蒙特利尔认知评估量表(MoCA)评分、简易智能精神状态检查量表(MMSE)评分及日常生活活动能力量表(ADL)评分均得到显著改善,且治疗组改善幅度更明显(P<0.05)。结论美金刚联合盐酸多奈哌齐能有效缓解和消除AD患者的精神行为障碍,全面改善和提升患者的日常生活能力。Objective To probe into the efficacy of memantine combined with hydrochloride donepezil for patients with Alzheimer＇ s disease. Methods 98 Alzheimer＇s disease patients from June 2013 to June 2015 were selected and randomly divided into the treatment group and control group,49 cases in each group. The control group was treated with hydrochloride donepezil,and the treatment group was treated with memantine combined with hydrochloride donepezil. The clinical efficacy,mental and behavioral disorders,activities of daily living,incidence of adverse reactions of the patients in two groups were compared and analyzed. Results The total effective rate in the treatment group was 93. 88%,which was significantly higher than 79. 59% of the control group（ P〈0. 05）; after treatment,the BEHAVE- AD scores,the MoC A scores,and the MMSE scores in the two groups were significantly increased,and the increase in the treatment group was more obvious（ P〈0. 05）. Conclusion Memantine combined with hydrochloride donepezil could alleviate and eliminate mental and behavioral disorders effectively,and enhance the overall improvement in the patient＇s activities of daily living for Alzheimer＇s patients.

关 键 词：阿尔茨海默病 精神行为障碍 日常生活能力 美金刚 盐酸多奈哌齐 

分 类 号：R969.4[医药卫生—药理学] R971.9[医药卫生—药学]