双屏散预防小儿热性惊厥效果研究  

Study on Shuangping San in Prevention of Children With Febrile Seizure

作　　者：张静敏[1] 梁文旺[1] 洪金玲[1] 旷乐[1] 

机构地区：[1]广西中医药大学附属瑞康医院儿科,广西南宁530011

出　　处：《中国卫生标准管理》2016年第13期131-133,共3页China Health Standard Management

摘　　要：目的：观察双屏散对小儿FS发作的预防效果。方法将120例FS患儿随机分成三组，即治疗组、对照组、空白对照组，每组各40例。治疗组：双屏散每日一剂，分早晚二次开水冲服，共服用30 d后停药。感染期间仅予常规治疗（抗感染、解热、对症处理等）。对照组：感染期间予常规治疗（同上）外，于每次感染时如体温＞37.3℃者，予苯巴比妥片，3～5 mg／（kg·d），分2～3次口服，维持用药至体温恢复正常，共预防用药一年。空白对照组：仅于感染期间予常规治疗（同上）。三个组观察随访期均为2年。结果（1）三个组，各组内比较，纳入观察后呼吸道感染总次数、发热总次数、FS总次数均较纳入观察前降低（P＜0.01）。但组间比较中，观察组在减少呼吸道总次数和发热总次数方面疗效优于对照组和空白对照组（P＜0.01），而对照组与空白对照组比较差异无统计学意义（P＞0.05）。（2）三个组纳入观察后FS总次数均较纳入观察前减少，但观察组、对照组与空白对照组比较差异有统计学意义（P＜0.01），观察组服用双屏散后FS总次数逐年减少，对照组在第一观察年中，FS总次数下降，疗效与观察组相当，但第二观察年FS总次数有所反弹，此时与观察组比较差异有统计学意义（P＜0.01）。结论（1）双屏散具有良好防治小儿反复呼吸道感染、降低发热发生率、防治FS效果，其防治FS作用，推测与其能够提高机体免疫功能有关。（2）于发热时口服苯巴比妥具有预防惊厥发作作用，但停药后复发的可能较高。（3）随着年龄增长，体质、免疫、抗病能力的增强，FS具有自愈趋向。ObjectiveObservation on Shuangping San to prevent children with FS effect.Methods120 cases of FS were randomly divided into three groups,namely,treatment group,control group,blank control group,each group of 40 cases. Treatment group：A daily dose of Shuangping san,mixing in boiled water for oral taking in the morning and evening,Observation of stopping drug after 30 days. During infection only routine therapy （antipyretic,anti infection and symptomatic treatment）. Control group：During infection received routine treatment（ibid.）, in each during infection if the temperature〉37.3℃ were treated with phenobarbital tablets,3 to 5 mg / （kg·d）,2 to 3 times a day oraly, maintenance medication to body temperature returned to normal,a total of preventive medication a year. Blank control group：conventional treatment was given only during the infection （same as above）. The three groups were observed and folowed up for 2 years.Results（1）Three groups,within each group comparison,the total number of respiratory infection,the total number of times of fever,and the total frequency of FS were lower than those before the observation （P〈0.01）. But inter group comparison,in observed group in reducing the total number of the total number of respiratory tract and fever has better effect than the control group and blank control group （P〈0.01）,while the control group and the blank control group,the difference was not statisticaly significant （P〉0.05）.（2）After the three groups were included in the observation,the total number of FS were significantly decreased compared with those before the observation,but the observation group,the control group and the blank control group had significant difference（P〈0.01）. Observation group was treated with Shuangping San,the total number of FS decreased year by year. Control group during the first year,the total number of FS decreased,the curative effect was equivalent to the observation group. But in the second year,total number of FS rebound,a

关 键 词：双屏散 小儿 热性惊厥 预防 

分 类 号：R971[医药卫生—药品]