HPLC-MS/MS测定城市废水中的10种药物与个人护理用品  

Determination of 10 pharmaceuticals and personal care products in waste water by HPLC-MS/MS

作　　者：卢红选[1] 刘卫国[1,2] 

机构地区：[1]中国科学院地球环境研究所黄土与第四纪地质国家重点实验室,西安710061 [2]西安交通大学人居环境与建筑工程学院,西安710049

出　　处：《地球环境学报》2016年第4期425-430,共6页Journal of Earth Environment

基　　金：国家自然科学基金项目(41572157)~~

摘　　要：采用固相萃取技术对水样进行预处理,结合液相色谱-串联质谱分析方法(HPLC-MS/MS),建立了同时检测城市废水中包括扑热息痛、萘普生、磺胺甲恶唑、磺胺二甲嘧啶、三氯生、双氯芬酸钠、三氯卡班、盐酸四环素、盐酸土霉素、吉非罗平在内共计10种药物与个人护理用品(PPCPs)的分析检测方法。采用中性条件萃取水样,控制上样流速为3—5 mL?min^(–1),用甲醇溶液洗脱。纯水的平均加标回收率为40.8%—104.5%,相对标准偏差为5.0%—25.5%(n=3)。应用所建立的分析方法,对西安浐河表层水进行了分析。结果表明:该方法可用于城市废水PPCPs的检测。10种目标物质中,共检测到4种,其含量为1.4—15.0 ng?L^(–1)。Background, aim, and scope Pharmaceuticals and personal care products（PPCPs） represent a variety of chemical, widely used by consumers on a daily basis which include prescription and non-prescription drugs, cosmetics, cleansers, detergents and fragrance produces. PPCPs are considered potentially hazardous compounds because some are ubiquitous, persistent, and biologically active compounds with recognized endocrine disrupting functions（Daughton and Ternes, 1999）. These compounds have been widely detected in various environmental matrices throughout the world including rivers（Glen et al, 2003; Tixier et al, 2003; Yu and Chu, 2009; Zhang et al, 2011; Wu et al, 2014）, lakes（Buser and Theobald, 1998; Glen et al, 2003; Tixier et al, 2003; Blair et al, 2013; Ferguson et al, 2013; Zhu et al, 2013）, oceans（Weigel et al, 2002; Del Rosario et al, 2014）, groundwater（Barnes et al, 2008）, waste and drinking water（Carmona et al, 2014） and food（Wu et al, 2012; Baron et al, 2014）. Detection methods of PPCP include spectrophotometry, gas chromatography, liquid chromatography and electrophoresis. The recent advances in analytical instrumentation have allowed the unequivocal identification and confirmation of the presence of any compound at very low levels using LC-MS-2. The multiple reaction monitoring（MRM） allows monitoring two transitions between precursor and product ions. It is possible to quantify and confirm the presence of PPCPs at very low concentration levels. However, due to the absence of official monitoring protocols, there is an increasing demand of analytical methods that allow the determination of those compounds in order to obtain more information regarding their behavior and fate in the environments. Therefore, we proposed here a method for the determination of ten pharmaceuticals and personal care products, including acetaminophen, naproxen, diclofenac, sulfamethoxazole, sulfadimidine, triclosan, triclocarban, tetracycline hydrochloride, oxytetracycline and gemfibrozile, in wast

关 键 词：固相萃取 高效液相色谱—串联质谱 药物与个人护理品 城市废水 

分 类 号：X832[环境科学与工程—环境工程]