基于灰色筛选法对大肠癌处方规律分析  

Regularity of Prescriptions Treating Colorectal Cancer Based on Grey Screening Method

作　　者：谌松霖 庞雁[2,3] 张利红[4] 朱慧[2] 李敬[2] 

机构地区：[1]天津中医药大学研究生院,天津300193 [2]天津市人民医院,天津300121 [3]天津中西医结合肿瘤研究所,天津300121 [4]南开大学,天津300071

出　　处：《中国实验方剂学杂志》2016年第15期220-226,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：江西省研究生创新专项资金项目(YC2015-S356);天津中医药大学中西医结合学院研究生教育校外创新实践基地科技创新基金项目(ZXYCX201510)

摘　　要：目的:探讨灰色筛选法在大肠癌处方用药规律研究中的应用。方法:通过纳入标准,收集大肠癌处方312首,涉及260味中药,累计用药2 363频次。对处方标准化后,进行"证型-药性-频次"数据采集,采用灰色筛选法分析大肠癌方剂的组方规律。结果:中医治疗大肠癌的处方以扶正培本为主,需注重清热解毒、活血化瘀、理气止血法的辅助应用,用药应考虑补益不忘祛邪,以体现中医的整体观与辨证论治思想。通过对核心药物分析,确定大肠癌治疗用药常以补虚、清热、活血化瘀为主。灰色关联度前5位为防风、黄芩、地榆、大黄、地黄,并演化得到5个基础新处方。结论:表明灰色理论联合多元分析的灰色筛选法,符合中医"辨证论治"思想,得出的大肠癌用药规律及新处方,为临床用药开阔了思路。Objective： To investigate the application of the grey screening method in the research of the prescriptions treating colorectal cancer（ CRC）. Method： According to the inclusion criteria,132 cases of prescriptions were collected,involving 260 herbal medicines,with the cumulative frequency of 2 363 times.Through the self-built ‘syndrome-herbal properties-frequency database＇,the grey screening method was adopted to analyze the rules of traditional Chinese medicine（ TCM） prescriptions for CRC. Result： In prescribers for TCM in treatment of CRC,doctors gave priority to strengthening and consolidating body resistance,and also consideration to clearing heat-toxicity, promoting blood circulation for removing blood stasis, and regulating Qi-flowing for hemostasis. Moreover,strengthening vital Qi and eliminating pathogenic factor should be taken into account,which reflects TCM＇s holism of and treatment based on syndrome differentiation. The analysis on core drugs shall be made to determine that the treatment of CRC medicines often had effects in tonifying deficiency,clearing heat,promoting blood circulation for removing blood stasis. The top 5 herbs with the hugest grey correlation degree are Saposhnikoviae Radix, Scutellariae Radix, Sanguisorbae Radix,Rhei Radix et Rhizoma, Rehmanniae Radix,and evolved into 5 basic prescriptions. Conclusion： The grey theory,in the combination of the grey screening method for multivariate analysis,conforms to the thought of ‘treatment based on syndrome differentiation＇in TCM,and provides new ideas for clinical medications.

关 键 词：灰色筛选 大肠癌 处方规律 辨证论治 

分 类 号：R287[医药卫生—中药学]