血清降钙素原对非脓毒症重症患者 疾病严重程度的预测价值  

The prognostic value of serum procalcitonin on severity of illness in non-sepsis critically ill patients

作　　者：马军宇[1] 王书鹏[1] 陈德生[1] 段军[1] 李晨[1] 李刚[1] 

机构地区：[1]中日友好医院SICU,北京100029

出　　处：《中华危重病急救医学》2016年第8期688-693,共6页Chinese Critical Care Medicine

摘　　要：目的：探讨非脓毒症重症患者血清降钙素原（PCT）水平与疾病严重程度和不同应激因素之间的可能关系，以及其对预后的预测价值。方法采用回顾性病例对照研究方法，分析2013年8月至2015年12月中日友好医院外科重症加强治疗病房（ICU）收治的非脓毒症重症患者的临床资料，纳入年龄≥18岁、ICU住院时间＞3d的患者。收集患者入ICU24h内血清PCT值、急性生理学与慢性健康状况评分系统Ⅱ（APACHEⅡ）评分、序贯器官衰竭评分（SOFA），并统计28d病死率。患者分组：根据原发病分为创伤应激组、卒中应激组和非感染性炎症应激组；根据血清PCT水平分为正常组、低水平组、中等水平组、高水平组；根据28d预后分为存活组和死亡组。比较不同组间患者的基本资料，采用Pearson或Spearman相关法分析各参数间的相关性；采用受试者工作特征曲线（ROC）评估PCT对非脓毒症重症患者预后的评估价值。结果共纳入非脓毒症重症患者94例，其中创伤应激组28例，卒中应激组30例，非感染性炎症应激组36例；PCT正常组32例，低水平组18例，中等水平组18例，高水平组26例；28d存活组78例，死亡组16例。①非脓毒症重症患者血清PCT水平与APACHEⅡ、SOFA评分呈显著正相关（r1＝0.688、r2＝0.771，均P＝0.000）。②创伤应激组PCT水平较卒中应激组和非感染性炎症应激组明显升高〔μg/L：4.43（0.86，11.72）比0.28（0.16，5.85）、2.39（0.13，4.11），均P＜0.01〕；创伤应激组和卒中应激组APACHEⅡ评分（分：13.9±7.5、13.9±7.0比9.4±4.4）、SOFA评分〔分：7.0（4.0，9.0）、5.0（3.0，8.0）比4.0（2.0，6.0）〕及28d病死率〔21.4%（6/28）、33.3%（10/30）比0（0/36）〕均较非感染性炎症应激组显著增高（均P＜0.05）。创伤应激组PCT异常率较卒中应激组及非感染性炎症组显著升高〔100.0%（28/28）比33.3%（10/30）、66.7Objective To evaluate the correlation between serum procalcitonin （PCT） level and severity of diseases caused by different kinds of stress factors, and to identify the prognostic value of PCT on the prognosis in non-sepsis critically ill patients. Methods A retrospective case control study was conducted. The clinical data of non-sepsis critically ill patients with age of ≥ 18 years admitted to surgery intensive care unit （ICU） of China-Japan Friendship Hospital from August 2013 to December 2015 and stayed for more than 3 days were enrolled. The PCT level in the first 24 hours, acute physiology and chronic health evaluation Ⅱ （APACHE Ⅱ） score, sequential organ failure assessment （SOFA） score and 28-day mortality were recorded. Patients were divided into different groups by the original injury, including trauma stress group, stroke stress group and non-infection inflammation stress group. According to PCT level, patients were divided into PCT normal group, low level group, medium level group and high level group. Furthermore, patients were divided into survival group and non-survival group according to 28-day prognosis. The clinical data of patients were compared among the groups, and the correlations among different markers were analyzed with Pearson or Spearman correlation analysis. The predictive value of PCT on prognosis of non-sepsis critically ill patients was evaluated with receiver operating characteristic curve （ROC）. Results Ninety-four non-sepsis critical ill patients were enrolled, with 28 patients in trauma stress group, 30 in stroke stress group, and 36 in non-infection inflammation stress group, as well as 32 patients in PCT normal group, 18 in low level group, 18 in medium level group, and 26 in high level group. Of them, 78 survivors and 16 non-survivors were found. ① The PCT level of non-sepsis critically ill patients was significantly positively correlated with APACHE Ⅱ score and SOFA score （r1 = 0.688, r2 = 0.771, both P = 0.000）. ② The PCT level in trauma str

关 键 词：降钙素原 非脓毒症 应激 严重程度 预后 

分 类 号：R459.7[医药卫生—急诊医学]