循环微小RNA作为脓毒症生物标志物的研究进展  

Progress in circulating microRNAs as biomarkers of sepsis

作　　者：林海焕 莫泽珣[2] 苏和毅 郭振辉[2] 

机构地区：[1]广州中医药大学研究生学院,广东广州510010 [2]广州军区广州总医院老年重症医学科,广东省老年感染与脏器功能支持重点实验室,广州市老年感染与脏器功能支持重点实验室,广东广州510010

出　　处：《中华危重病急救医学》2016年第8期752-755,共4页Chinese Critical Care Medicine

基　　金：基金项目：广东省科技计划项目（2012A061400010）;广东省广州市科技计划项目（20150820253）;广东省广州市科研条件建设项目（7411675081103）;广东省广州市科学研究专项（2014J4100033）

摘　　要：脓毒症是机体对感染失控反应导致的能够威胁生命的器官衰竭，其具有发病急、机制复杂、病死率高等特点，早期诊治尤为重要。目前用于诊断脓毒症的实验室指标的敏感性和特异性不够理想。微小RNAs （microRNAs）是一类不具备编码蛋白质能力的RNA，在细胞质中合成，主要通过微囊泡形式进入循环，并且能够稳定存在于循环中，可以被快速检测。通过总结以循环miRNAs作为脓毒症生物标志物的研究成果，分析miR-150、miR-133a、miR-122、miR-223、miR-4772、miR-297和miR-574-5p等常见miRNAs在脓毒症过程中的差异表达特点，推测其对脓毒症诊断和预后具有评估价值，可能成为诊断脓毒症及判断预后的生物标志物。Sepsis is as life-threatening organ failure caused by a dysregulated host response to infection, with urgent onset, complex mechanism and high mortality. Its early diagnosis and treatment is particularly important. However, the sensitivity and specificity of current laboratory markers for the diagnosis of sepsis is not ideal. MicroRNAs represent a novel group of small RNA molecules that do not encode for proteins. MicroRNAs are synthesized in the cytoplasm and transferred to circulation primarily by micro-vesicles, and they are stable in circulation and can be rapidly detected. The researches regarding circulating miRNA as biomarkers of sepsis were collected to analyze the characteristics of differential expression of miRNAs including miR-150, miR-133a, miR-122, miR-223, miR-4772, miR-297 and miR-574-5p etc. in the pathogenesis of sepsis, which suggest that they can be used as biomarkers for the diagnosis and prognosis of sepsis.

关 键 词：脓毒症 微小RNA 生物标记物 诊断 预后 

分 类 号：R459.7[医药卫生—急诊医学]