维生素E对人群心脑血管疾病死亡及总死亡的风险研究的Meta分析  

Effect of vitamin E supplementation on cardiovascular disease mortality and all-cause deaths:a Meta-analysis of randomized controlled trials

作　　者：兰欣[1] 党少农[1] 赵亚玲[1] 屈鹏飞[1] 米白冰[1] 颜虹[1] 

机构地区：[1]西安交通大学公共卫生学院流行病与卫生统计系,陕西西安710061

出　　处：《中国预防医学杂志》2016年第7期504-508,共5页Chinese Preventive Medicine

基　　金：中国营养学会营养科研基金--帝斯曼专项科研基金(2014-014)

摘　　要：目的应用Meta分析评价维生素E补充对心脑血管疾病死亡的影响作用。方法计算机检索Pubmed,EMBASE,OVID,Healthstar,Cochrane database,Google Scholar等数据库,查找1980-2014年有关维生素E补充与心脑血管疾病死亡的随机对照试验研究文献,并筛选符合条件的研究。研究结果指标为心脑血管疾病死亡和总死亡,效应指标为反映死亡发生风险的相对危险度（RR,95%CI）。采用RevMan 5.1软件进行Meta分析,并进行亚组分析和敏感性分析。全部文献均应用Jadad评分进行质量评价。结果共纳入11个随机对照试验（randomized controlled trials,RCTs）研究,除2篇质量较低之外,其余文献质量都较高。11篇研究显示了维生素E对心脑血管疾病死亡无影响RR=1.00,95%CI（0.95-1.06）;11篇研究显示了维生素E对总死亡无影响RR=1.02,95%CI（0.99-1.06）。亚组分析结果显示性别、随访时间、有无其他干预措施、维生素E的剂量以及有无心脑血管疾病病史均对此研究结论无显著影响。结论人群补充维生素E未发现增加心脑血管疾病死亡及总死亡的风险。Objective To evaluate the effect of vitamin E supplementation on cardiovascular disease death by Meta analysis. Methods The database such as Pubmed,EMBASE,OVID,Healthstar,Cochrane database,Google Scholar were searched to collect randomized controlled trials（RCTs）about vitamin E supplementation and cardiovascular disease mortality from 1980 to 2014and eligible studies were screened.Cardiovascular disease mortality and all-cause death served as study indicator and relative risk（RRand 95%CI）as effective indicator.Meta-analysis was conducted by using RevMan 5.1software and subgroup analysis and sensitivity analysis were also performed.Jadad score was used for the evaluation of literature quality. Results A total of 11 RTCs were selected into the Meta analysis,9with high quality and 2with low quality.All 11 studies showed that vitamin E had no effect on both cardiovascular disease mortality（RR=1.00,95%CI：0.95-1.06）,and all-cause death rate（RR=1.02,95%CI：0.99-1.06）.Subgroup analysis revealed that gender,follow-up time,other interventions,doses of vitamin E and the history of cardiovascular diseases did not influence the study results. Conclusions Vitamin E supplementation may not significantly increase the cardiovascular disease mortality and all-cause death rate.

关 键 词：维生素E 心脑血管疾病 心脑血管疾病死亡 随机对照试验 

分 类 号：R54[医药卫生—心血管疾病]