Identifying a Safe Range of Stimulation Current for Intraoperative Neuromonitoring of the Recurrent Laryngeal Nerve： Results from a Canine Model  

作　　者：Tao Li Gang Zhou Yang Yang Zhi-Dong Gao Peng Guo Zhan-Long Shen Xiao-Dong Yang Qi-Wei Xie Ying-Jiang Ye Ke-Wei Jiang Shan Wang 

机构地区：[1]Department of Gastrointestinal Surgery, Surgical Oncology Laboratory, Peking University People's Hospital, Peking University, Beijing 100044, China

出　　处：《Chinese Medical Journal》2016年第15期1830-1834,共5页中华医学杂志（英文版）

摘　　要：Background： lntraoperative neuromonitoring （IONM） of the recunent laryngeal nerve （RLN） has been widely applied during thyroid surgery. However, the sale range of stimulation intensity for IONM remains undetermined, Methods： Total thyroidectomies were performed on twenty dogs, and their RLNs were stimulated with a current of 5 20 mA （step-wise in 5 mA increments） for 1 min. The evoked electromyography （EMG） of vocal muscles before and after supramaximal stimulation were recorded and compared. Acute microstructural morphological changes in the RLNs were observed immediately postoperatively under an electron microscope. Results： The average stimulating threshold for RLNs stimulated with 15 mA and 20 mA showed no significant changes compared to the unstimulated RLNs （15 mA group： 0.320 ± 0.123 mA vs. 0.315 ±0.097 mA, P =0.847; 20 mA group： 0.305 ± 0.101 mA vs. 0.300 ＋ 0.103 mA, P = 0.758）. Similar outcomes were shown in average evoked EMG amplitude （15 mA group： 1,026 ± 268 p.V xs. 1,021 ± 273 p.V, P = 0.834; 20 mA group： 1,162 ± 275 μV vs. 1,200 ± 258μV, P = 0.148）. However, obvious acute microstructural morphological changes were observed in the nerves that were stimulated with 20 mA. Conclusions： A stimulation intensity less than 15 mA might be safe for IONM of the RLN.Background： lntraoperative neuromonitoring （IONM） of the recunent laryngeal nerve （RLN） has been widely applied during thyroid surgery. However, the sale range of stimulation intensity for IONM remains undetermined, Methods： Total thyroidectomies were performed on twenty dogs, and their RLNs were stimulated with a current of 5 20 mA （step-wise in 5 mA increments） for 1 min. The evoked electromyography （EMG） of vocal muscles before and after supramaximal stimulation were recorded and compared. Acute microstructural morphological changes in the RLNs were observed immediately postoperatively under an electron microscope. Results： The average stimulating threshold for RLNs stimulated with 15 mA and 20 mA showed no significant changes compared to the unstimulated RLNs （15 mA group： 0.320 ± 0.123 mA vs. 0.315 ±0.097 mA, P =0.847; 20 mA group： 0.305 ± 0.101 mA vs. 0.300 ＋ 0.103 mA, P = 0.758）. Similar outcomes were shown in average evoked EMG amplitude （15 mA group： 1,026 ± 268 p.V xs. 1,021 ± 273 p.V, P = 0.834; 20 mA group： 1,162 ± 275 μV vs. 1,200 ± 258μV, P = 0.148）. However, obvious acute microstructural morphological changes were observed in the nerves that were stimulated with 20 mA. Conclusions： A stimulation intensity less than 15 mA might be safe for IONM of the RLN.

关 键 词：Canine Model NEUROMONITORING Recurrent Laryngeal Nerve Safe Stimulation Intensity Thyroid Surgery 

分 类 号：S823.2[农业科学—畜牧学] Q954.55[农业科学—畜牧兽医]