益气活血化痰法对老年心力衰竭合并肺部感染患者GDF-15及suPAR的影响  

Effects of Yiqi Huoxue Huatan Method on GDF-15 and su PAR in Elderly Heart Failure Complicated with Pulmonary Infection Patients

作　　者：李魏[1] 俞兴群[1] 

机构地区：[1]安徽中医药大学第一附属医院,安徽合肥230031

出　　处：《中医药临床杂志》2016年第7期959-962,共4页Clinical Journal of Traditional Chinese Medicine

基　　金：安徽中医药大学科学研究研基金项目(2015qn028)

摘　　要：目的:观察益气活血化痰法对老年心力衰竭合并肺部感染患者GDF-15及su PAR的影响。方法:纳入心力衰竭合并肺部感染患者60例,随机分为治疗组和对照组各30例。对照组予以常规西医治疗,治疗组在此基础上加用益气活血化痰法(参麦注射液、丹参酮ⅡA磺酸钠注射液入液静滴,咳喘平口服或鼻饲),2组分别于入院及治疗2周后检测患者血清生长分化因子-15(GDF-15)、可溶性尿激酶型纤溶酶原激活物受体(su PAR)的水平,并对临床疗效进行评估。结果:治疗2周后,2组GDF-15、su PAR水平均明显降低,组间比较治疗组明显低于对照组;治疗组有效率为86.7%,对照组总有效率为63.3%,治疗组有效率明显优于对照组,差异有统计学意义。结论:益气活血化痰法能够有效降低患者GDF-15及su PAR水平,能够改善患者预后。Objective： To observe the clinical therapeutic effects of Yiqi Huoxue Huatan method on GDF-15 and suPAR in elderly heart failure complicated with pulmonary infection patients. Methods： 60 patients with heart failure complicated with pulmonary infection were randomly divided into treatment group and control group, 30 cases in each group. The control group was treated with conventional western medicine, and the treatment group was given Yiqi Huoxue Huatan method therapy besides western medicine, GDF-15 and suPAR were detected when admission and two weeks after treatment. Meanwhile, the clinical efficacy was evaluated. Results： After treatment for two weeks, GDF-15 and suPAR in both groups were decreased significantly（P〈0.05） , GDF-15 and suPAR in treatment group were significantly lower than control group（P〈0.05）, the total effective rate of the treatment group was 86.7%, which was significantly better than than the control group（63.3%） . Conclusion： The method of Yiqi Huoxue Huatan method could effectively reduce the levels of GDF-15 and suPAR in patients, thus to improve prognosis.

关 键 词：老年心力衰竭 肺部感染 益气活血化痰法 生长分化因子15 可溶性尿激酶型纤溶酶原激活物受体 

分 类 号：R259[医药卫生—中西医结合]