膦甲酸钠治疗扁平疣及对血清脂质过氧化物和血清细胞因子的影响研究  

Research of influence by foscarnet sodium treating flat wart on serum lipid peroxide and cytokines

作　　者：孟繁俊[1] 

机构地区：[1]河南省商丘市第一人民医院皮肤科,476100

出　　处：《中国实用医药》2016年第18期3-4,共2页China Practical Medicine

摘　　要：目的观察膦甲酸钠联合微波治疗扁平疣的临床疗效及其对血清脂质过氧化物(LPO)和血清细胞因子的影响。方法 108例顽固性扁平疣患者随机分为对照组和观察组,各54例。对照组采用微波治疗,观察组采用膦甲酸钠联合微波治疗。比较两组的疗效、复发率及治疗后白细胞介素(IL)、干扰素γ(IFN-γ)和LPO水平。结果观察组有效率高于对照组(P<0.05),复发率低于对照组(P<0.05);治疗后观察组IL-2、IL-4、IL-6、IL-10、IFN-γ、LPO水平优于对照组(P<0.05)。结论膦甲酸钠联合微波治疗扁平疣临床疗效好,复发率低,并能显著改善患者血清IL、IFN-γ及LPO水平,平衡血清Th1/Th2细胞因子。Objective To observe clinical effect by foscarnet sodium combined with microwave in the treatment of flat wart, and its influence on serum lipid peroxide（LPO） and cytokines. Methods A total of 108 intractable flat wart patients were randomly divided into control group and observation group, with 54 cases in each group. The control group received microwave for treatment, and the observation group received foscarnet sodium combined with microwave. Comparison was made on curative effect, recurrence rate, interleukin（IL）, interferon-γ（IFN-γ） and LPO levels after treatment between the two groups. Results The observation group had higher effective rate（P〈0.05） and lower recurrence rate than the control group（P〈0.05）. After treatment, the observation group had all better IL-2, IL-4, IL-6, IL-10, IFN-γ and LPO levels than the control group（P〈0.05）. Conclusion Combination of foscarnet sodium and microwave provides precisely clinical effect and low recurrence rate in treating flat wart, and it can remarkably improve serum IL, IFN-γ and LPO levels, and balance Th1/Th2 cytokines in patients.

关 键 词：膦甲酸钠 微波 扁平疣 脂质过氧化物 细胞因子 

分 类 号：R752.52[医药卫生—皮肤病学与性病学]