糖尿病性胃肠功能紊乱的影响因素  

Factors associated with diabetic gastrointestinal dysfunction

作　　者：王晓青[1] 杨建华[1] 段宇珠[1] 琚坚[1] 

机构地区：[1]昆明医科大学第二附属医院特需病房科,云南省昆明市650000

出　　处：《世界华人消化杂志》2016年第20期3209-3214,共6页World Chinese Journal of Digestology

摘　　要：目的:对伴有胃肠功能紊乱与不伴胃肠功能紊乱的糖尿病患者的相关资料、数据进行整理,分析糖尿病患者发生胃肠功能紊乱的相关因素,及其相关因素在糖尿病性胃肠功能紊乱发病机制中的作用.方法:选取昆明医科大学第二附属医院于2006-2015间住院的符合糖尿病诊断条件的180例患者,其中80例诊断为糖尿病性胃肠功能紊乱,设定为病例组;100例无胃肠功能紊乱糖尿病患者,设定为对照组.比较两组的性别、年龄、糖尿病患病时间的长短、胰岛功能(C-肽释放试验)、糖化血红蛋白、空腹血糖、餐后2 h血糖、糖尿病并发症(糖尿病性肾病、糖尿病性眼病、冠心病、糖尿病酮症、脑动脉硬化、外周血管动脉粥样硬化、糖尿病性外周神经病变)等相关指标并进行统计学分析.结果:病例组0、1、2 h C-肽均低于同一时间点上的对照组0、1、2 h C-肽(1.79 ng/m L±1.54 ng/m L vs 1.98 ng/m L±1.20 ng/m L,P=0.367)、(2.86 ng/m L±2.33 ng/m L vs 3.97ng/m L±2.77 ng/m L,P=0.05)、(3.33 ng/m L±2.58 ng/m L vs 8.44 ng/m L±3.62 ng/m L,P<0.001),差异有统计学意义.病例组中冠心病、脑动脉硬化患者所占比例均高于对照组(25%vs 7%,P=0.01)、(26.25%vs24%,P=0.73).病例组中糖尿病肾病、糖尿病眼病、糖尿病酮症、外周神经病变患者所占比例均高于对照组(37.5%vs 16%,P=0.02)、(45%vs 15%,P<0.001)、(22.5%vs20%,P=0.72)、(51.25%vs 21%,P<0.001).结论:糖尿病性胃肠功能紊乱的发生与胰岛功能、患糖尿病时间的长短、糖尿病合并冠心病、糖尿病肾病、糖尿病眼病、外周神经病变有一定的关系,胰岛功能差、患糖尿病时间长、合并冠心病、糖尿病肾病、糖尿病眼病、外周神经病变的患者更有可能合并糖尿病性胃肠功能紊乱.而糖尿病性胃肠功能紊乱与性别、年龄、糖化血红蛋白、空腹血糖、餐后2 h血糖、糖尿病酮症、外周血管动脉粥样硬化及脑动脉粥样硬化没AIM：To compare the data of diabetic patients with diabetic gastrointestinal dysfunction and those without to identify factors associated with gastrointestinal dysfunction in patients with diabetes mellitus.METHODS：One hundred and eighty diabetes mellitus patients treated from 2006 to 2015 at the Second Affiliated Hospital of Kunming Medical University were included,including80 with diabetic gastrointestinal dysfunction as a case group,and 100 without diabetic gastrointestinal dysfunction as a control group.The two groups were compared with regard to gender,age,medical history,islet function（C-peptide release test）,glycosylated hemoglobin,fasting blood-glucose,2 h postprandial blood glucose,diabetic complications（diabetic nephropathy,diabetic eye disease,coronary heart disease,diabetic ketosis and cerebral artery elasticity,peripheral vascular atherosclerosis,and diabetic peripheral neuropathy） and other related paramters.RESULTS：There was no significant difference in sex distribution between the two groups（P= 0.083）.C-peptide levels at 0,1,and 2 h were significantly lower in the case group than in the control group（1.79 ng/mL±1.54 ng/mL vs 1.98 ng/mL±1.20 ng/mL,P = 0.367;2.86ng/mL±2.33 ng/mL vs 3.97 ng/mL±2.77 ng/mL,P = 0.05;3.33 ng/mL±2.58 ng/mL vs 8.44ng/mL±3.62 ng/mL,P 0.001）.Fasting blood glucose was lower in the case group than in the control group（8.53 mmol/L±3.61 mmol/L vs 9.10 mmol/L±3.70 mmol/L,P = 0.30）.The proportions of patients with peripheral atherosclerosis and those with coronary heart disease in the case group were significantly higher than those in the control group（25%vs 7%,P = 0.01;26.25%vs 24%,P = 0.73）.The proportions of diabetic nephropathy,diabetes,eye diseases,diabetic ketosis,and peripheral neuropathy were also significantly higher in the case group than in the control group（37.5%vs 16%,P = 0.02;45%vs 15%,P 0.001;22.5%vs 20%,P = 0.72;51.25%vs 21%,P 0.001）.CONCLUSION：The occurrence of diabetic gastrointestinal dysfunction is associated with isle

关 键 词：糖尿病性胃肠功能紊乱 胃轻瘫 糖尿病性肠病 

分 类 号：R587.2[医药卫生—内分泌]