Apelin-13 as a novel target for intervention in secondary injury after traumatic brain injury  

作　　者：Hai-jun Bao Hai-yang Qiu Jin-xia Kuai Cheng-jie Song Shao-xian Wang Chao-qun Wang Hua-bin Peng Wen-can Han Yong-ping Wu 

机构地区：[1]Department of Pathology,Xuzhou Medical College [2]Department of Forensic Medicine,Xuzhou Medical College [3]Department of Physiology,Xuzhou Medical College

出　　处：《Neural Regeneration Research》2016年第7期1128-1133,共6页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.81302612;the Natural Science Foundation of Jiangsu Province of China,No.12KJB310018;a grant from the Student Innovation Training Program of China,No.201410313023Z

摘　　要：The adipocytokine,apelin-13,is an abundantly expressed peptide in the nervous system.Apelin-13 protects the brain against ischemia/reperfusion injury and attenuates traumatic brain injury by suppressing autophagy.However,secondary apelin-13 effects on traumatic brain injury-induced neural cell death and blood-brain barrier integrity are still not clear.Here,we found that apelin-13 significantly decreases cerebral water content,mitigates blood-brain barrier destruction,reduces aquaporin-4 expression,diminishes caspase-3 and Bax expression in the cerebral cortex and hippocampus,and reduces apoptosis.These results show that apelin-13 attenuates secondary injury after traumatic brain injury and exerts a neuroprotective effect.The adipocytokine,apelin-13,is an abundantly expressed peptide in the nervous system.Apelin-13 protects the brain against ischemia/reperfusion injury and attenuates traumatic brain injury by suppressing autophagy.However,secondary apelin-13 effects on traumatic brain injury-induced neural cell death and blood-brain barrier integrity are still not clear.Here,we found that apelin-13 significantly decreases cerebral water content,mitigates blood-brain barrier destruction,reduces aquaporin-4 expression,diminishes caspase-3 and Bax expression in the cerebral cortex and hippocampus,and reduces apoptosis.These results show that apelin-13 attenuates secondary injury after traumatic brain injury and exerts a neuroprotective effect.

关 键 词：traumatic hippocampus cortex suppressing caspase minutes autophagy destruction hemisphere edema 

分 类 号：R651.15[医药卫生—外科学]