血清缺血修饰白蛋白与脂联素对早期急性心肌梗死患者的检测价值  

Detection value of serum ischemia modified albumin and adiponectin at patients with acute myocardial infarction at the early stages

作　　者：赵志明[1] 杨文东[2] 

机构地区：[1]山东省惠民县人民医院检验科,惠民251712 [2]利津县第二人民医院检验科与病理科

出　　处：《临床医学》2016年第7期5-7,共3页Clinical Medicine

摘　　要：目的探讨早期急性心肌梗死(AMI)患者血清缺血修饰白蛋白(IMA)及脂联素(APN)的相关性及临床价值。方法选择胸痛发作在6 h内的疑似AMI患者180例,其中108例确诊为AMI(AMI组),余72例为非AMI(NAMI组),同期选择50例健康体检者为正常对照组,检测血清IMA(游离钴比色法)及APN(ELISA法)水平,进行统计学处理与分析。结果 AMI组血清IMA水平显著高于对照组(t=24.541,P<0.01)及NAMI组(t=10.711,P<0.01),血清APN水平显著低于对照组(t=7.453,P<0.01)及NAMI组(t=7.109,P<0.01)。NAMI组血清IMA水平显著高于对照组(t=15.079,P<0.01),血清APN水平与对照组比较差异未见统计学意义(t=1.016,P>0.05)。早期AMI患者血清IMA水平与血清APN水平呈负相关(r=-0.549,P<0.01)。结论早期AMI患者血清IMA与血清APN呈负相关,联合检测疑似早期AMI患者血清IMA与APN水平有助于AMI的早期临床诊断,也有利于临床疗效观察。Objective To investigate the relationship between serum ischemia modified albumin（ IMA） and the level of adiponectin（ APN） in early acute myocardial infarction（ AMI） patients and its clinical value. Methods A total of 180 cases of suspected AMI within 6 h onset of chest pain were selected,among them,108 patients were diagnosed with AMI（ AMI group）and 72 cases without AMI（ NAMI group）,and 50 healthy physical examination in the same period as the normal control group.The serum IMA（ cobalt free colorimetric method） and the APN（ ELISA） levels were detedcted. Results The serum IMA in the AMI group was significantl higher than that in the control group（ t = 24. 541,P〈0. 01）,serum APN level was significantly lower than that in the control group（ t = 7. 453,P〈0. 01）. The serum IMA in the AMI group was significantly higher than that of NAMI group（ t = 10. 711,P〈0. 01）,serum APN level was significantly lower than that in the NAMI group（ t = 7. 109,P〈0. 01）. The serum IMA in the NAMI group was significantly higher than that in the control group（ t = 15. 079,P〈0. 01）,the serum APN level had no significantly different compared with control group（ t = 1. 016,P 1. 016）. The serum IMA level was negatively correlated with the serum APN level in early AMI patients（ r = 0. 549,P〈0. 01）. Conclusion The serum IMA level is negatively correlated with the serum APN level in early AMI patients,the joint detection of serum IMA and APN levels in suspected early AMI patients helps to the early clinical diagnosis of AMI,also it is helpful for the clinical curative effect observation.

关 键 词：急性心肌梗死 缺血修饰白蛋白 脂联素 相关性 

分 类 号：R542.22[医药卫生—心血管疾病]