阻塞性睡眠呼吸暂停综合征合并高血压与血管紧张素转换酶基因多态性的Meta分析  

Relationship between obstructive sleep apnea syndrome complicated with hypertension and angiotensin converting enzyme gene polymorphism: a Meta-analysis

作　　者：聂莉[1] 徐健[1] 陈济明[1] 李一禄[1] 

机构地区：[1]广东医学院附属南山医院呼吸内科,深圳518052

出　　处：《临床医学》2016年第7期10-12,共3页Clinical Medicine

摘　　要：目的综合评价血管紧张素转换酶（ACE）基因多态性与阻塞性睡眠呼吸暂停综合征（OSAS）合并高血压的关系。方法检索Pub Med、Cochrane Library、中国学术期刊全文数据库、中国生物医学文献数据库、万方资源数据库、重庆维普网并手工检索相关期刊,全面收集ACE基因多态性与OSAS合并高血压关系的病例对照研究文献,提取有效数据进行Meta分析。结果最终纳入4篇文献。Meta分析结果显示：亚洲人群的OSAS合并高血压组D/Ⅰ和DD/Ⅱ分布的合并OR分别为0.59（95%CI：0.39~0.89,P=0.011）和0.40（95%CI：0.16~0.98,P=0.044）。结论亚洲人群ACE基因多态性与OSAS合并高血压易感性有关。但因研究质量及研究样本的存在明显局限性,需更多高质量、大规模的临床研究加以验证。Objective To evaluate the relationship between angiotensin-converting gene enzyme（ACE）gene polymorphism and hypertension in obstructive sleep apnea syndrome（OSAS）patients. Methods Searched and identified from PubMed,Cochrane Li-brary,China Academic Journals full-text database,Chinese Biomedical Literature Database,Wanfang Resource Database and Chongqing VIP database. According to inclusion to evaluate the quality of choice experiment,and then extract the valid data for Meta-analysis. Results four articles were included. Meta analysis showed that the pooled OR for frequency D/Ⅰand DD/Ⅱdistri-bution were 0. 59（95% CI：0. 39 -0. 89,P =0. 011）and 0. 40（95% CI：0. 16 - 0. 98,P = 0. 044）in OSAS with hypertension of Asians,respectively. Conclusion There are correlation of hypertension with ACE gene polymorphism in Asian OSAS populations. However,due to the quality and the limitations of the study,need more high-quality,large-scale clinical trial to be verified.

关 键 词：阻塞性睡眠呼吸暂停综合征 高血压 血管紧张素转换酶 基因多态性 META分析 

分 类 号：R766[医药卫生—耳鼻咽喉科] R544.1[医药卫生—临床医学]