核因子κB信号通路在炎症性肺部疾病中的作用  

Role of nuclear factor-κB signaling pathway in inflammatory lung diseases

作　　者：潘秀和 刘超波[1] 孙俊[1] 李燕[1] 李明才[1] 

机构地区：[1]宁波大学医学院免疫学研究室,浙江宁波315211

出　　处：《中国药理学与毒理学杂志》2016年第7期762-769,共8页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金(81070034);国家自然科学基金(81370166);宁波市科技惠民项目(2015C50018);浙江省公益技术应用研究(2016C37139)~~

摘　　要：核因子(NF)κB是一种广泛存在多种组织细胞的转录因子,其信号通路的异常激活能导致哮喘和慢性阻塞性肺疾病(COPD)等肺部炎症性疾病的产生,而抑制其活性可有效缓解以上疾病的发生和发展。本文对NF-κB的生物学特征及其信号通路在哮喘和COPD等炎症性疾病中的作用以及NF-κB抑制剂治疗哮喘和COPD等炎症性疾病中的进展进行综述,为进一步阐述哮喘和COPD等肺部炎症性疾病的发病机制、预防及控制提供参考。Nuclear factor（NF）-κB is widely expressed in various types of tissue cells. Abnormal activation of NF-κB signaling pathway can lead to the initiation and progression of asthma,chronic obstructive pulmonary disease（COPD）and other lung inflammatory diseases,but inhibition of its activity can effectively alleviate the occurrence and development of these diseases. In this paper,we review biological characteristics of NF-κB,role of NF-κB signaling in asthma,COPD and other inflammatory lung diseases,and potential application of NF-κB inhibitors in clinical treatment of these inflammatory lung diseases. It will provide a valuable reference for further study on pathogenesis,prevention,and control of lung inflammatory diseases.

关 键 词：核因子ΚB 哮喘 慢性阻塞性肺疾病 抑制剂 

分 类 号：R563[医药卫生—呼吸系统]