潜在T_2类造影剂Fe_3O_4@BSA纳米粒子的合成及性能  

Synthesis and Property of Fe_3O_4@BSA Nanoparticles as Promising T_2 Contrast Agents

作　　者：龚建波[1] 仲聪 黄燕[1] 张岐[1,3] 华明清 张小燕[1] 吴静波[1] 

机构地区：[1]江苏大学化学化工学院,江苏镇江212013 [2]江苏大学京江学院化学化工学院,江苏镇江212013 [3]海南省精细化工重点实验室,海南海口570228

出　　处：《精细化工》2016年第8期856-861,879,共7页Fine Chemicals

基　　金：国家自然科学基金(21471069/21261008/21302071);江苏省高等自然科学研究面上项目(14KJB150006);江苏省博士后科研资助计划项目(1401050C);江苏大学高级人才科研启动基金(14JDG054);江苏大学大学生科研立项(13A059)~~

摘　　要：制备了Fe_3O_4@BSA磁性纳米功能材料,包裹在Fe_3O_4纳米粒子表面的牛血清白蛋白(BSA)主要起到分散剂和稳定剂的作用。通过傅里叶变换红外光谱、X射线衍射、透射电子显微镜及热重分析对合成的Fe_3O_4@BSA纳米粒子进行了表征和分析。结果表明,制备的Fe_3O_4@BSA纳米粒子中BSA质量分数约为18.9%。体外成像结果表明,随着Fe_3O_4@BSA纳米粒子浓度的增加,T2成像信号增强,具有明显的阴性造影效果。于0.5 T外磁场下,测得Fe_3O_4@BSA纳米粒子的横向弛豫率(transverse relaxivity,r2)为148.18 L/(mmol·s)。结果表明,Fe_3O_4@BSA纳米粒子能够作为一种潜在的T2类磁共振成像造影剂。Fe3O4@ BSA nanoparticles（ NPs） were successfully synthesized,and bovine serum albumin（ BSA） coated upon the surface of Fe3O4 NPs played the role of a stabilizer and disperser. The asprepared Fe3O4@BSA NPs were characterized and analyzed by Fourier transform infrared spectroscopy（ FTIR）,X-ray diffraction（ XRD）,transmission electron microscopy（ TEM） and thermogravimetric analysis（ TGA）. The results suggested the successful synthesis of Fe3O4@BSA NPs and mass fraction of BSA was about 18. 9% in Fe3O4@BSA NPs. Magnetic resonance（ MR） imaging in vivo showed that the T2 MRI signals enhanced with the increase of the concentration of Fe3O4@BSA NPs concentrations,which presented an obvious negative MRI effect of Fe3O4@ BSA NPs. The transverse relaxivity（ r2） of the Fe3O4@BSA NPs was evaluated as 148. 18 L /（ mmol · s） at 0.5 T. These preliminary studies indicated that the obtained Fe3O4@BSA NPs could be used as promising T2 contrast agents for magnetic resonance imaging.

关 键 词：磁共振成像 造影剂 弛豫率 FE3O4 功能材料 

分 类 号：TQ450.45[化学工程—农药化工]