艾滋病患者抗病毒治疗前后CD4^+/CD8^+比值变化及其意义  

The changes of CD4^+/ CD8^+ ratio in human immunodeficiency virus and acquired immunodeficiency syndrome patients before and after the highly active antiretroviral therapy and its significance

作　　者：童珑[1] 马健强[1] 谭覃[1] 曹富鹏[1] 何倩红[1] 

机构地区：[1]佛山市顺德区疾病预防控制中心,广东佛山528300

出　　处：《热带医学杂志》2016年第7期891-893,共3页Journal of Tropical Medicine

摘　　要：目的了解艾滋病患者治疗前后CD4^+/CD8^+比值变化情况及治疗前CD4^+/CD8^+比值对治疗时机选择的影响。方法对2006-2015年在顺德区接受抗病毒治疗的艾滋病患者治疗前后CD4^+/CD8^+比值及治疗前CD4^+/CD8^+比值与治疗后CD4^+T淋巴细胞数变化关系进行统计学分析。结果治疗后CD4^+/CD8^+比值表现为随治疗时间延长而不断增大,但增幅在减小;初始治疗年龄以及性别不影响CD4^+/CD8^+比值的变化(P>0.05);治疗前CD4^+/CD8^+比值<0.2与≥0.3的艾滋病患者相比,其治疗后CD4^+T淋巴细胞数差异有统计学意义(P<0.05),后者治疗后CD4^+T淋巴细胞数增长更明显。结论抗病毒治疗能有效提高CD4^+/CD8^+比值,但需保证治疗依从性;早期治疗效果更好,对于治疗前CD4^+/CD8^+比值<0.2的艾滋病患者应积极动员其开始抗病毒治疗。Objective To understand the changes of CD4^＋/CD8^＋ ratio in human immunodeficiency virus and acquired immunodeficiency syndrome patients（HIV / AIDS） before and after the highly active antiretroviral therapy（HAART） and explore the effect of the CD4^＋/CD8^＋ ratio before treatment on the treatment timing. Methods The CD4^＋/CD8^＋ ratio before and after the HAART, the relationship between CD4^＋/CD8^＋ ratio before the HAART and the CD4^＋T lymphocyte counts after the HAART in HIV / AIDS who received antiviral treatment in our area from 2006 to 2015 were analyzed statistically. Results The CD4^＋/CD8^＋ ratio was increased with the extension of treatment time, but the growth rate was decreased; the CD4^＋/CD8^＋ ratio were not affected by the initial treatment age and sex（P〉0.05）; The difference of CD4^＋ T lymphocyte counts in HIV / AIDS between the CD4^＋/CD8^＋ ratio less than 0.2 and more than 0.3 was statistically significant（P〈0.05）; the growth of CD4^＋ T lymphocyte counts was more obvious in the latter. Conclusion The HAART can improve the CD4^＋/CD8^＋ ratio effectively, but need to ensure the treatment compliance. The earlier the treatment begins the better the treatment effect. The HIV / AIDS patients with CD4^＋/CD8^＋ ratio less than 0.2 should be mobilize to start the HAART actively.

关 键 词：艾滋病 抗病毒治疗 CD4^+/CD8^+比值 

分 类 号：R512.91[医药卫生—内科学]