多目标同步优化黄马缓释喷雾膜剂的基质处方  

Multi-objective Simultaneous Optimization of Huang-ma Slow-release Membrane Spray Agent

作　　者：高倩[1] 刘新[1] 杨敏[2] 刘梅[2] 陈薇[2] 

机构地区：[1]重庆医科大学,重庆400016 [2]重庆市中医院,重庆400021

出　　处：《中药材》2016年第4期833-836,共4页Journal of Chinese Medicinal Materials

摘　　要：目的:优选黄马缓释喷雾膜剂的基质组成,测定体外释放度及透皮性能,考察其释药规律。方法:采用正交设计法,以聚乙烯醇(PVA17-88)、乙醇和甘油的用量为因素,以成膜性能、士的宁和盐酸小檗碱在8 h内的累积释放率为指标,确定最优基质处方组成;用Franz扩散池法测定体外释放度及体外透皮渗透率。结果:优选得到的最优基质处方为PVA17-88 5%,乙醇15%,甘油6%;黄马缓释喷雾膜剂的成膜性能较好,8 h内的体外释放良好,具有一级动力学特征。结论:该喷雾膜剂处方和制备工艺可行;制剂可以喷涂均匀,药物释放缓慢,成膜后对溃疡面具保护作用,对创面刺激性小;药膜的黏附性、柔韧性均较好。Objective： To optimize the material composition of Huang-ma slow-release membrane spray agent and to examine its delivery evaluation and transdermal release law in vitro. Methods： The dosage of PVA17-88,ethanol and glycerin were used as factors,the film-forming properties,the release rate of strychnine and berberine hydrochloride in eight hours were adopted as indexes to optimize the molding process; the release rate and transdermal release were examined in vitro by using Franz diffusion cells. Results： The optimum extraction technology in vitro was 5% of PVA17-88,15% of ethanol,and 6% of glycerin; Huang-ma slow-release membrane spray agent had the characteristics of good release and kinetic equation with good film-forming properties in eight hours. Conclusion： The formula and the preparation methods are both feasible,the drug can be sprayed evenly,quantitatively slow released; it has a protective effect on wound with little irritation after filming,and has good adhesion and flexibility as well.

关 键 词：缓释喷雾膜剂 基质组成 正交设计 成膜性能 

分 类 号：R286.3[医药卫生—中药学]