安徽省孕期妇女麻疹抗体水平的现况调查  

The level of measles antibody pregnant Women in Anhui Province

作　　者：张宁[1] 周淑洁[1] 王斌冰[1] 苏颖[1] 刘丹青[1] 

机构地区：[1]安徽省疾病预防控制中心免疫预防科,安徽合肥230601

出　　处：《中华疾病控制杂志》2016年第7期690-693,共4页Chinese Journal of Disease Control & Prevention

摘　　要：目的 了解安徽省孕妇麻疹抗体水平,为控制8月龄以内儿童麻疹发病提供科学依据。方法 采用多阶段抽样方法,抽取2013年12月～2014年6月在门诊进行产前检查的孕妇作为调查对象,对其进行问卷调查并采集孕妇外周静脉血分离血清,采用酶联免疫吸附法（enzyme-linked immunosorbent assay,ELISA）检测麻疹IgG抗体阳性率和几何平均浓度。结果 共调查1141名孕妇,血清麻疹IgG抗体阳性率为91.15%,几何平均浓度为572.03mlU/ml,城市孕妇的血清麻疹抗体阳性率和几何平均浓度均高于农村孕妇（均有P〈0.05）,高年龄组孕妇血清麻疹抗体几何平均浓度高于低年龄组孕妇（F=6.92,P〈0.001）,不同麻疹患病史的孕妇抗体几何平均浓度的差异有统计学意义（F=6.31,P=0.002）。结论 加强育龄期未怀孕妇女的麻疹疫苗预防接种工作,不但能够控制这一人群本身发病情况,还是降低8月龄以下婴儿发病的主要措施。Objective To evaluate serum levels of of measles antibody among pregnant women of Anhui province so as to provide evidence for measles control in infants younger than eight months. Methods Multistage sampling was a- dapted to select pregnant women who went to outpatient clinlc for prenatal examination from December 2013 to June 2014. They were asked to fill in a questionnaire. Blood samples were collected and centrifuged, serum was separated and tested for measles antibody levels with enzyme linked immunosorbent assay（ELISA）. Results Of 1 141 pregnant women, the positive rate was 91.15% and the geometric mean concentration （GMC） was 572.03 mlU/ml for measles antibody IgG. The measles antibody IgG positive rate and GMC of urban pregnant women were higher than that of rural ones （ all P 〈 0. 05 ）. The measles antibody IgG GMC of elder pregnant women was higher than young ones（ F = 6. 92,P 〈 0. 001 ）. Con- clutions Immunization of measles for child-bearing age women is a main measure for measles control in not only adults but also infants younger than 8 months.

关 键 词：孕妇 麻疹 抗体 病毒 问卷调查 横断面研究 

分 类 号：R511.1[医药卫生—内科学] R446.622[医药卫生—临床医学]