IL-28Brs12979860位点与乙肝病毒感染后自发清除及干扰素治疗应答关系的Meta分析  

Association of IL-28B rs12979860 with spontaneous HBV clearance and interferon treatment response: a Meta-analysis

作　　者：于风雪[1] 姜乐[1] 马宁[2] 张晓琳[2] 权媛[3] 刘殿武[2] 

机构地区：[1]河北医科大学第二医院科研处,河北石家庄050000 [2]河北医科大学流行病学教研室,河北石家庄050017 [3]河北省胸科医院结核科,河北石家庄050041

出　　处：《中华疾病控制杂志》2016年第7期707-711,共5页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金青年科学基金(81402729);河北省自然科学基金(H2015206152);河北省科技厅课题(13277732D)

摘　　要：目的 探索白细胞介素28B（interleukin-28B,IL-28B）基因rs12979860位点与乙型肝炎病毒（hepati-tis B virus,HBV）感染后自发清除及干扰素治疗应答的关系。方法 检索2010年1月1日～2015年8月31日PubMed、Embase、中文科技期刊全文数据库、万方数据库、中国生物医学文献数据库、中国期刊全文数据库公开发表文献,对符合纳入和排除标准文献提取数据后采用Stata12.0软件进行Meta分析。结果 共纳入12篇文献,根据研究目的分为两组：A组为HBV自发清除组和持续感染组,共5篇文献;B组：干扰素治疗应答组和非应答组,共9篇文献。Meta分析结果：rs12979860位点与HBV感染后自发清除无关联（OR=0.96,95%CI：0.76～1.20,P=0.700）;rs12979860位点与乙型肝炎e抗原阳性慢性HBV感染后干扰素治疗应答无关联（OR=0.93,95%CI：0.43～2.00,P=0.848）,而突变基因型TC＋TT降低了乙型肝炎e抗原阴性慢性HBV感染后干扰素治疗应答（OR=0.47,95%CI：0.25～0.87,P=0.016）。结论 IL-28B基因的rs12979860位点突变基因型TC＋TT降低了乙型肝炎e抗原阴性慢性HBV感染后干扰素治疗的应答。Objective To investigate the association of SNP-rsI2979860 in Interleukin- 28B （IL-28B） gene with spontaneous Hepatitis B Virus （HBV）clearance and interferon treatment response in patients with chronic hepatitis B. Methods Data published from January l, 2010 to August 31, 2015 were retrieved from PubMed,Embase,CNKI,Wanfang database, VIP database and CBM disc. The recta-analysis was performed to analyze the data. Results Twelve papers were obtained and were divided into two groups according to the purpose of the study. Group A included five articles about rs12979860 and spontaneous HBV clearance, and group B included nine articles about rs12979860 and interferon treatment response. The meta-analysis showed that there was no association between rs12979860 and spontaneous HBV clearance （ OR = 0. 96,95% CI：0. 76-1.20,P = 0. 700） and the response after interferon treatment for HBeAg-positive patients （ OR =0.93, 95% CI：0. 43-2. 00,P = 0. 848）, respectively. There was positive correlation between rs12979860 and the re- sponse after interferon treatment for HBe-negative patients, which manifested that the mutant genotype TC ＋ TT significantly reduced the response after interferon treatment for HB e-negative patients. （ total OR = 0. 47, 95% CI：0. 25-0. 87,P = 0. 016）. Conclusions The mutant genotype TC ＋ TF located on rs12979860 from gene IL-28B reduced the response after the interferon treatment for HBe-negative patients.

关 键 词：基因 肝炎 乙型 慢性 META分析 

分 类 号：R512.62[医药卫生—内科学]