颈椎康热融压敏胶贴质量控制研究  

Study on the quality control method for Jingzhuikang Plaster based on hot-melt pressure sensitive adhesives

作　　者：康阿龙[1] 王卫峰[2] 汤迎爽[3] 

机构地区：[1]解放军第四五一医院,西安710054 [2]陕西省中医药研究院中药研究所,西安710003 [3]解放军第三二三医院,西安710054

出　　处：《西北药学杂志》2016年第4期360-363,共4页Northwest Pharmaceutical Journal

摘　　要：目的建立颈椎康热融压敏胶贴的质量检测方法。方法采用专属性薄层色谱法鉴定方中4味主药;高效液相色谱法检测该药中的主要指标成分葛根素含量。色谱条件:色谱柱:Diamonsil C_(18)柱(250 mm×4.6 mm,5μm);流动相:甲醇-水(25∶75);流速:1.0mL·min^(-1);检测波长:250nm;柱温:室温。结果薄层鉴别斑点清晰,分离效果良好,空白无干扰;葛根素含量在0.101 6~1.101 6μg范围内线性关系符合要求(r=0.999 7),方法加样回收率为100.4%,RSD为2.17%(n=6)。结论经研究建立的方法,可作为该药的质量检测手段。Objective To establish a quality standard for Jingzhuikang Plaster based on hot-melt pressure sensitive adhesives.Methods Eucommiae cortex,Angelicae sinensis radix,Corni fructus and puerariae radix were identified by TLC.The content of puerarin in Jingzhuikang Plaster was determined by HPLC.Diamonsil C_（18）（250mm×4.6mm,5μm）column was used.The mobile phase consisted of methanol-water（25∶75）at normal flow rate.The detection wavelength was set at 250 nm.Results The spots in TLC were clear.Puerarin showed a good linear relationship within the range of 0.101 6-1.101 6μg（r=0.999 7）.The average recovery was 100.4%,and the RSD was 2.17%（n=6）.Conclusion The established methods can be used for Jingzhuikang Plaster quality control.

关 键 词：葛根素 颈椎康热融压敏胶贴 质量标准 HPLC TLC 

分 类 号：R284[医药卫生—中药学]