盐酸帕罗西汀肠溶缓释片的制备及体外释放研究  

Preparation and in vitro release evaluation of paroxetine hydrochloride enteric-coated sustained-release tablets

作　　者：谢向阳[1] 任宏英[2] 李银科[1] 陈晨[1] 史琼枝[1] 廖翔茹 陈鹰[1] 

机构地区：[1]广州军区武汉总医院药剂科,武汉430070 [2]山西大学化学化工学院分析化学系,太原030006

出　　处：《西北药学杂志》2016年第4期395-399,共5页Northwest Pharmaceutical Journal

摘　　要：目的制备盐酸帕罗西汀肠溶缓释片,并对其体外释放度进行考察。方法采用HPMC K100LV和HPMC K4M作为骨架材料,以水乳糖为填充剂制备盐酸帕罗西汀缓释片芯,再使用Eudragit L30D-55包肠溶衣,制成盐酸帕罗西汀肠溶缓释片,并采用f_2相似因子法评价自制制剂和参比制剂在释放介质中的体外释放行为。结果体外释放度实验显示,自制制剂和参比制剂的f_2相似因子值大于50。结论制备的盐酸帕罗西汀肠溶缓释片的释药行为与参比制剂的体外释放行为相似。Objective To prepare enteric-coated sustained-release tablets of paroxetine hydrochloride,and to investigate in vitro drug release behavior.Methods The sustained-release tablets of paroxetine hydrochloride were prepared by HPMC K100 LV and HPMC K4 M,and lactose monohydrate as the filling agent.The enteric-coated tablets were prepared by Eudragit L30D-55.The release behavior similarity was investigated between the reference and self-prepared tablets in release media.Similar factor f_2 was used to evaluate the similarity of release curves.Results The in vitro release data proved that the values of f_2 was more than 50.Conclusion The release behaviors of paroxetine hydrochloride enteric-coated sustained-release tablets and reference tablets were similar.

关 键 词：盐酸帕罗西汀 肠溶缓释片 体外释放 

分 类 号：R944[医药卫生—药剂学]