血浆谷氨酸脱氢酶活性测定在肝胆疾病中的临床应用评价  

The clinical significance of plasma GLDH activity in patients with liver disease

作　　者：易婷婷[1] 罗光成[1] 胡帅[1] 刘素兰[1] 张国元[1] 蒋兴亮[1] 

机构地区：[1]川北医学院附属医院检验科,四川南充637000

出　　处：《川北医学院学报》2016年第4期532-534,共3页Journal of North Sichuan Medical College

基　　金：天晴肝病研究基金(TQGB20150016)

摘　　要：目的：探讨血浆谷氨酸脱氢酶（glutamate dehydrogenase,GLDH）活性测定在肝脏疾病中的临床意义。方法：采用速率法检测229例肝功能异常者（急性肝损伤25例;慢性乙型肝炎60例;肝硬化47例;肝衰竭31例;胆道梗阻性疾病29例;肝癌37例）及120例健康体检者（作为对照组）的血浆GLDH活性,并与AST、ALT、ALT、GGT等常用肝胆疾病指标进行比较分析。结果：本室采用速率法测定GLDH活性的参考区间为4.4～13.3 U/L。胆道梗阻性疾病和肝癌患者血浆GLDH较对照组明显升高（P〈0.05）,胆道梗阻性疾病患者的GLDH/AST比值也明显高于对照组（P〈0.05）。血浆GLDH浓度与AST浓度呈显著的正相关（r=0.230,P〈0.001）。血浆GLDH浓度与肝损伤程度相关,随病情好转而降低。结论：胆道梗阻性疾病和肝癌患者血浆GLDH升高最为明显,GLDH可作为判断肝细胞损伤程度和疗效观察的指标。Objective：To investigate the clinical significance of glutamate dehydrogenase （GLDH） in patients with liver disease. nethods：A total of 229 patients with liver disease （25 patients with acute hepatitis,60 CHB patients,47 patients with liver cirrhosis,31 patients with liver failure,29 patients with biliary obstruction,37 patients with liver carcinoma） and 120 healthy subjects were enrolled. The liver enzymes of GLDH, AST, ALT, ALT and GGT were determined. Results ： The activity of GLDH in liver diseases, especially in patients with biliary obstruction and liver carcinoma, were significantly higher than that in healthy controls （ P 〈 0.05 ）. The ratio of GLDH to AST in patients with biliary obstruction was significantly higher than that in healthy controls （ P 〈 0.05）. The activities of GLDH closely related to the severity of liver damage and correlated with AST （ r = 0. 230, P 〈 0. 001 ）. Conclusion ： The activity of GLDH was significantly increased in patients with biliary obstruction and liver carcinoma, and may be a biochemical marker for diagno- sing and evaluating the liver injury.

关 键 词：谷氨酸脱氢酶 肝损伤 天门冬氨酸氨基转移酶 

分 类 号：R123.1[医药卫生—环境卫生学]