化疗药物渗漏性损伤治疗新方法的临床应用及相关机理  

Clinical application and related mechanism of new treatments for chemotherapy extravasation injury

作　　者：蒋红[1,2] 杜华英[3] 贾艾敏[2] 姚亚希 杨明辉[1,2,4] 

机构地区：[1]川北医学院附属医院风湿免疫研究所,四川南充637000 [2]川北医学院附属医院医学研究中心,四川南充637000 [3]川北医学院附属医院烧伤科,四川南充637000 [4]川北医学院附属医院检验科,四川南充637000

出　　处：《川北医学院学报》2016年第4期570-571,585,共3页Journal of North Sichuan Medical College

摘　　要：目的:探讨化疗药物渗漏性损伤治疗新方法的临床应用及相关机理。方法:随机抽取本院2012年3月至2015年3月肿瘤科化疗药物渗漏性损伤患者100例为研究对象,随机分为两组,每组50例,对照组使用2%山莨菪碱进行局部封闭治疗后50%Mg SO4持续加压冷敷1 d后热敷,观察组使用2%山莨菪碱联合1%利多卡因进行局部封闭治疗后50%Mg SO4持续加压冷敷1 d后热敷,观察比较两组临床应用效果。结果:观察组治疗总有效率显著高于对照组,皮肤损伤愈合时间显著短于对照组,差异比较具有统计学意义。结论:2%山莨菪碱联用1%利多卡因能有效治疗化疗药物渗漏性损伤,值得临床推广应用。Objective：To evaluate the clinical application and related mechanism of new treatments for chemotherapy extravasation injury. Methods ：100 cases of ontology patients with chemotherapy extravasation injury who were hospitalized during March 2012 and March 2015, were randomly divided into two groups. 50 patients in the control group were given 2% anisodamine for local closure therapy while patients in the observation group were given 2% anisodarnine combined with 1% lidocaine. All the patients were given cold compress with sustained pressure for 1 day and subsequently hot compress. 50% MgSO4 was used both in the cold compress and the hot compress. The clinical effect was observed between the two groups. Results ：The total effective rate of observation group was sig- nificantly higher than that of the control group, the time of skin wound healing was significantly shorter than that of the control group, the difference was statistically significant. Conclusion ：2% anisodamine combined with 1% lidoeaine can effectively treat chemotherapy ex- travasation injury. This therapy is worthy of clinical application and application.

关 键 词：化疗药物 渗漏性损伤 治疗方法 机理 

分 类 号：R452[医药卫生—治疗学]