次大面积肺栓塞患者生存率相关影响因素分析  

Analysis of factors influencing the survival rate of patients with submassive pulmonary embolism

作　　者：张倩[1] 王敏[1] 

机构地区：[1]保定市第一中心医院检验科,河北保定071000

出　　处：《中国医学前沿杂志（电子版）》2016年第7期123-126,共4页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的探讨影响次大面积肺栓塞患者生存率的相关影响因素及D-二聚体水平对患者生存率的影响。方法收集2010年1月至2014年12月于本院就诊的次大面积肺栓塞患者的一般资料,随访12个月,观察患者的生存情况。对其相关危险因素进行Logistic回归分析。结果本研究共纳入85例患者,其中,男52例（61.18%）,女33例（38.82%）,中位年龄为59岁（37~75岁）,1年总生存率为54.32%。单因素分析显示,年龄（P〈0.001）、D-二聚体水平（P=0.013）、伴发恶性肿瘤（P〈0.001）与患者生存率相关。多因素分析显示,年龄（P〈0.001;OR=1.22,95%CI：1.138~1.309）、D-二聚体水平（P=0.024;OR=1.710,95%CI：1.138~1.309）、伴发恶性肿瘤（P=0.018;OR=0.229,95%CI：0.068~0.775）为影响患者生存率的独立因素。结论年龄、D-二聚体水平、伴发恶性肿瘤与次大面积肺栓塞患者的生存率相关,且为影响患者生存率的独立因素,年龄≥63岁、D-二聚体水平≥500 ng/ml、伴发恶性肿瘤的次大面积肺栓塞患者生存率低,临床上应高度关注此类患者并给予积极治疗。Objective To investigate the factors influencing the survival rate of patients with submassive pulmonary embolism and the effect of D-dimer level on survival rate. Method Patients who comfirmed submassive pulmonary embolism from January 2010 to December 2014 in our hospital were included in this study, recorded the clinical information. All patients were followed up by 12 months. Logistic regression analysis was carried out on the related risk factors. Result The data of 85 submassive pulmonary embolism patients were analyzed retrospectively, included 52 cases（61.18%） of men, 33 cases（38.82%） of women, medium age was 59 years（37 to 75 years）. The 1-year survival rate was 54.32%. Univariate analysis showed that age（P〈0.001）, D-dimer level（P = 0.013）, and complicating malignancy（P〈0.001） were associated with the lower survival rate. Multi factor analysis showed that： age（P〈0.001; OR = 1.22, 95%CI： 1.138 ~ 1.309）, D-dimer level（P = 0.024; OR = 1.710, 95%CI： 1.138 ~ 1.309）, and complicating malignancy（P = 0.018, OR = 0.229, 95%CI： 0.068 ~ 0.775） were the independent factors affecting the survival rate. Conclusion Age, D-dimer level, complicating malignancy are related with the survival rate of submassive pulmonary embolism. Patients with age ≥ 63 years old, D-dimer level ≥ 500 ng/ml, complicating malignancy have lower survival rate.

关 键 词：年龄 D-二聚体 肺栓塞 次大面积 生存率 

分 类 号：R563.5[医药卫生—呼吸系统]