核苷(酸)类似物抗病毒治疗对乙型肝炎病毒相关性肝癌术后临床转归的影响  

Efficacy of nucleoside analogues antiviral therapy on clinical outcome for HBV-related primary hepatic carcinoma patients after hepatectomy

作　　者：姚红兵[1] 文明波[1] 华赟鹏[2] 黄高[1] 李桂花[1] 

机构地区：[1]中国人民解放军第一八一医院肝胆胰外科,桂林市541002 [2]中山大学附属第一医院肝外科,广州市510080

出　　处：《实用医学杂志》2016年第15期2468-2470,共3页The Journal of Practical Medicine

基　　金：广东省科技计划项目(编号:2014A020212626)

摘　　要：目的:探讨核苷(酸)类似物(NAs)抗病毒治疗对乙型肝炎病毒(HBV)相关性肝癌术后临床转归的影响。方法:回顾性分析经根治性切除术治疗的HBV相关性肝癌患者临床资料156例,根据术后是否接受抗病毒治疗将入组患者分为对照组(n=80)和观察组(n=76)。对比两组术后血清HBV DNA载量、无复发生存(RFS)及总生存(OS)。结果:术后1周、1、2及3个月时,观察组血清HBV DNA载量均显著低于对照组(P<0.05)。对照组和观察组术后1、3及5年RFS率组间比较差异有统计学意义(P<0.05)。对照组和观察组术后1、3及5年OS率组间比较差异有统计学意义(P<0.05)。结论:HBV相关性肝癌术后给予规范的NAs抗病毒治疗可显著改善预后、延长生存期。Objective To evaluate the efficacy of nucleoside analogues（NAs） antiviral therapy on clinical outcome for hepatitis B virus（HBV）-related primary hepatic carcinoma patients after hepatectomy.Methods The clinical data of 156 HBV-related primary hepatic carcinoma patients after hepatectomy were retrospectively analyzed..According to whether accepted postoperative antiviral treatment, all patients were divided into control group（n = 80）and observation group（n = 76）. The serum HBV DNA capacity, recurrence-free survival（RFS）and overall survival（OS）were compared between two groups. Results One week, 1 month, 2months and 3 months after operation, the serum HBV DNA capacity of observation group was significantly lower than that of control group（P〈0.05）. One year, 3 years and 5 years after operation, intergroup comparison of RFS rate of both groups showed statistical significance（P〈0.05） and 1 year, 3 years and 5 years after operation, the difference of OS rate of both groups indicated statistical significance（P〈0.05）. Conclusion Standard NAs antiviral treatment for HBV-related primary hepatic carcinoma patients after hepatectomy,can improve prognosis and prolong survival time. The inhibition the HBV copy active may be its mechanism.

关 键 词：核苷(酸)类似物 乙型肝炎病毒相关性肝癌 抗病毒 肝切除术 

分 类 号：R512.62[医药卫生—内科学] R735.7[医药卫生—临床医学]