尘螨特异性IgE阳性儿童支气管哮喘脱敏治疗临床研究  

A clinic study on desensitization treatment of bronchial asthma with positive specific IgE to dust mite in children

作　　者：蔡幸生[1] 朱勇斌[1] 林丽爱 黄育涛[1] 陈素华[1] 王金燕[1] 林彤彤[1] 

机构地区：[1]广东省揭阳市人民医院儿科,522000 [2]广东省揭阳市榕城区妇幼保健院,522000

出　　处：《实用医学杂志》2016年第15期2488-2490,共3页The Journal of Practical Medicine

基　　金：广东省揭阳市卫生局医学科研项目(编号:2001002)

摘　　要：目的：探讨尘螨特异性Ig E阳性儿童支气管哮喘脱敏治疗的临床疗效及疗程。方法：105例血清粉尘螨抗原阳性的支气管哮喘患儿在临床缓解后被随机分成观察组和对照组,对照组继续按哮喘诊疗常规进行治疗,观察组在对照组治疗基础上,予粉尘螨滴剂1～4号舌下含服脱敏治疗,治疗满25周时,比较两组哮喘复发情况。25周后,观察组再随机分成两组,观察Ⅰ组除停脱敏治疗外,其他治疗继续,观察Ⅱ组在观察Ⅰ组治疗的基础上,继续舌下含服粉尘螨滴剂4号至1年,比较两组哮喘复发情况。结果：粉尘螨滴剂舌下含服治疗组复发率、发作次数明少于对照组（均P〈0.05）。而观察Ⅰ组和观察Ⅱ组哮喘复发情况比较差异无显著性（均P〉0.05）。结论：尘螨特异性Ig E阳性支气管哮喘儿童通过脱敏治疗能减少其复发率及复发次数,疗程6个月即可。Objective To investigate the efficacy and the course of desensitization treatment in bronchial asthma with positive specific Ig E to dust mite in children. Methods A total of 105 children with bronchial asthma with positive specific Ig E to dermatophagoides farinae allergens were randomized into the observation group and the control group. Children in the control group were treated to continue anti-asthma according to the routine of prevention and treatment children with asthma. Chinldren in the observation group were treated by dermatophagoides farinae drops in addition to the treatment of children in the control group. The recurrence of asthma was compared between two groups at 25 weeks post-treatment. At 25 weeks post-treatment, children in the observation group was randomly divided into the observation group Ⅰ and group Ⅱ. Children in the observation groupⅠreceived continuous treatment except for desensitization treatment. Children in the observation group II received the sublingual immunotherapy with dermatophagoides farinae drops（No.4） for 1 year in addition to the treatment in the observation group Ⅰ. The recurrence of asthma was also compared between the two sub-groups. Results The rate and times of recurrence of asthma were lower in the observation group than those in the control group（P〈0.05）, with no significant differences between the observation group Ⅰ and groupⅡ（P〈0.05）. Conclusion The recurrent rate and frequency of asthma could be reduced by the sublingual immunotherapy with dermatophagoides farinae drops in children with asthma of positive specific Ig E to dust mite.The course of treatment may be half year long.

关 键 词：支气管哮喘 脱敏治疗 疗效 疗程 儿童 

分 类 号：R725.6[医药卫生—儿科]