核苷类抗病毒药群体药动学研究及应用  

Study and Application of Antiviral Nucleoside Population Pharmacokinetic

作　　者：陈美钦 王长连[1] 

机构地区：[1]福建医科大学药学院,福州350004 [2]福州市晋安区医院,福州350014

出　　处：《海峡药学》2016年第7期4-7,共4页Strait Pharmaceutical Journal

摘　　要：群体药动学运用经典药动学统计学相结合的方法来定量考察目标群体中药物浓度的影响因素,并应用于优化临床药物治疗方案。核苷类抗病毒药在临床抗病毒治疗中发挥重要的作用,此类药物的疗效、不良反应与其体内药物浓度息息相关,阿昔洛韦、更昔洛韦、泛昔洛韦、齐多夫定、恩曲他滨、拉米夫定和阿巴卡韦等核苷类抗病毒药的群体药动学研究促进该类药物在临床的合理应用。Population pharmacokinetics use Pharmacokinetics classic combination of statistical methods to quanti -fy the factor influencing the drug concentration in the target groups ,and can be applied to optimize the clinical drug treatment programs through the use of statistical methods .Nucleoside antiviral drugs play an important role in the clinical antiviral therapy ,the efficacy of these drugs ,adverse drug reactions and its concentration in the body is close-ly related to,the population pharmacokinetic study of acyclovir ,ganciclovir,famciclovir,zidovudine,emtricitabine, lamivudine and abacavir promote rational use of these drugs in the clinic .

关 键 词：群体药动学(PPK) 非线性混合效应模型(NONMEM) 核苷类抗病毒药 

分 类 号：R969.1[医药卫生—药理学]