异香豆素噁二唑类化合物的合成及除草活性  

Synthesis and herbicidal activity of several substituted isocoumarin oxadiazole

作　　者：时佳妹 霍静倩[1] 张哲[1] 张金林[1] 

机构地区：[1]河北农业大学植物保护学院,河北保定071001

出　　处：《农药学学报》2016年第4期530-534,共5页Chinese Journal of Pesticide Science

基　　金：国家自然科学基金资助项目(31171877)

摘　　要：为了寻找具有较高除草活性的异香豆素类化合物,设计合成了16个新型异香豆素噁二唑类化合物4a^4p,其结构均经核磁共振氢谱、碳谱及高分辨质谱确证。初步除草活性测定结果表明,部分目标化合物在500 mg/L下对马唐Digitaria sanguinalis L.和反枝苋Amaranthus retroflexus L.具有一定的除草活性,其中化合物4j(4-[5-(4-氯-苯基)-[1,2,4]噁二唑-3-基]-3-己基-6,7-二甲氧基异香豆素)的活性最好,对马唐和反枝苋的致死率分别为64%和62%。In order to get a series of isocoumarin compounds with high herbicidal activity, 16 substituted oxadiazole 4a-4p were synthesized. All the target compounds were characterized by^1 H NMR, ^13 C NMR and HRMS. Preliminary screening with Digitaria sanguinalis L. and Amaranthus retroflexus L. demonstrated that some of the target compounds exhibited herbicidal activity at the concentrations of 500 mg/L. 4j, 4-（5-（4-chlorophenyl）-1, 2, 4-oxadiazol-3-yl）-3-hexyl-6, 7-dimethoxy-1H-isochromen-1-one had the best effect to D. sanguinalis and A. retroflexus of which the mortality rates were 64% and 62%.

关 键 词：异香豆素 噁二唑 合成 除草活性 

分 类 号：O626.2[理学—有机化学] S482.4[理学—化学]