骨髓间充质干细胞分化过程中表观遗传调控机制的研究进展  

Research Progress on Epigenetic Regulation Mechanism in the Differentiation of Bone Marrow Mesenchymal Stem Cell

作　　者：王连庆[1] 翟俏丽[1] 赵培庆[1] 李涛[1] 

机构地区：[1]淄博市中心医院转化医学中心,淄博255036

出　　处：《生物技术通报》2016年第7期21-27,共7页Biotechnology Bulletin

基　　金：山东省自然科学基金项目(ZR2014HM042;ZR2015PH031;ZR2015HM031)

摘　　要：骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMMSCs)具有自我更新的能力和多向分化潜能,在体外可被诱导分化成多种细胞类型,在骨及软骨组织修复中具有重要的临床应用价值。为研发有效促进BMMSCs定向分化的药物,将BMMSCs更合理安全地应用于临床,有必要阐明表观遗传在BMMSCs分化过程中的调控机制。由于BMMSCs的异常分化可导致疾病的发生,其分化调控机制一直是研究的热点。表观遗传调控,如DNA甲基化、组蛋白乙酰化、组蛋白甲基化及非编码RNA等,对决定BMMSCs分化方向至关重要。阐明表观遗传在BMMSCs分化过程中的调控机制,将有助于研发有效促进BMMSCs定向分化的药物,更合理安全地将BMMSCs应用于临床。就BMMSCs分化中的主要表观遗传调控机制的最新研究进展做一综述,并进行了总结。Bone Marrow Mesenchymal Stem Cells（BMMSCs）,with the potential of self-renewal and multipotent differentiation,maydifferentiate to be several types of cells by induction,thus hold critical clinic values for the restoration of destroyed bones and cartilages.Inorder to investigate a medicine that may efficiently promote the directional differentiation of BMMSCs and thus using BMMSCs in clinic moresafely and reasonably,it is necessary to illustrate the epigenetic regulation mechanism in the differentiation process of BMMSCs.Abnormalregulation of BMMSCs differentiation may lead to development of several diseases,thus appropriate control of BMMSCs differentiationmechanism has been the hotspot topic of research.Epigenetic regulation,such as DNA methylation,histone acetylation,histone methylationand noncoding RNA,play critical roles in the regulation of BMMSCs differentiation.This review summarizes the progress on major epigeneticregulation mechanisms involved in BMMSCs differentiation in recent years.

关 键 词：骨髓间充质干细胞 细胞分化 表观遗传调控 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]