化学振荡法分析头孢拉定胶囊中头孢拉定的含量  

Analysis of the Cefradine in Capsule Using Chemical Oscillation Method

作　　者：原春兰[1] 任丽君[1] 柴瑞英 

机构地区：[1]宝鸡文理学院化学化工学院陕西省植物化学重点实验室,陕西宝鸡721013 [2]陕西省榆林市府谷县大昌汗学校,陕西榆林719400

出　　处：《化学试剂》2016年第8期751-754,794,共5页Chemical Reagents

基　　金：陕西省教育厅资助项目(06JC25)

摘　　要：采用BZ振荡体系,以甘氨酸-MnSO_4-KBrO_3-H_2SO_4-丙酮化学振荡体系为测量体系,研究了不同浓度的头孢拉定,对振荡体系振幅及周期的影响。结果表明,在8.59×10^(-5)~6.013×10^(-4)mol/L浓度范围内,头孢拉定对振荡体系的振幅及周期有较大影响,且头孢拉定的浓度与振幅及周期的改变值,均存在良好的线性关系,其线性方程为ΔA=1.091 9×105c+36.79;Δtp=2.048 1×105c+12.18,相关系数分别为0.995 5和0.990 1,从而建立了一种新的化学振荡法测定头孢拉定含量的方法。Using Belousov-Zhabotinskii（ BZ） oscillating reaction,effect of the different concentration Cefradine on the oscillating amplitude and the period in glycine-BrO_3^--Mn^（2＋）-H_2SO_4-CH_3COCH_3 chemical oscillation system was investigated. The results show that Cefradine has strong influence on the oscillating amplitude and the period in the range of 8. 59 × 10^（-5）~ 6. 013 × 10^（-4）mol / L,and the concentration of Cefradine has good linear relationship with the changes of the amplitude（ ΔA）,while the c（ where c is the concentration of Cefradine） is linear with Δtp. That fitted to the following linear regression equation： ΔA = 1. 091 9 ×105c ＋ 36. 79; Δtp= 2. 048 1 × 105 c ＋ 12. 18,with the regression coefficient 0. 995 5 and 0. 990 1. So a new determination method of Cefradine content using chemical oscillation technique is established.

关 键 词：B-Z振荡反应 甘氨酸 头孢拉定 分析 

分 类 号：R917[医药卫生—药物分析学]