鞣花鞣质肠道代谢产物urolithins研究进展  

Research progress of ellagitannin intestinal metabolite urolithins

作　　者：周本宏[1] 邱振鹏[2] 易慧兰 周丁山[1] 汪静[1] 吴玥[1] 

机构地区：[1]武汉大学人民医院,湖北武汉430060 [2]湖北中医药大学中药资源与中药复方教育部重点实验室,湖北武汉430065

出　　处：《中国中药杂志》2016年第16期2968-2974,共7页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(31570349)

摘　　要：鞣花鞣质是一类具有诸多生物活性的酚类化合物,近年来研究发现其发挥作用的物质基础与其肠道菌群代谢产物——尿石素密切相关。该研究就近几年国内外关于尿石素的结构特征、类型、分布,以及其改善前列腺、乳腺、结肠相关疾病,抗癌、抗氧化、抗炎等生物活性研究进行了综述,为开发和利用尿石素奠定基础。Ellagitannins is a kind of phenolic compounds with many biological activities. Recent studies have found that the effec- tive ingredients of these compounds have close relationship with their colon-derived bacteria metabolites, that is urolithins. The objec- tive of this study was to review the structure characteristics, types and distribution of urolithins, improvement in diseases related to prostate, breast and colon, as well as anti-cancer, anti-oxidation, anti-inflammation and other biological activities. The present review will lay the foundation for development and utilization of urolithins.

关 键 词：尿石素 代谢产物 分布 生物活性 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]