2型糖尿病合并高血压患者同型半胱氨酸与血管紧张素转换酶的相关性分析  

Relationship between homocysteine and angiotensin-converting enzyme in type 2 diabetes patients with hypertension

作　　者：张爽[1] 强雪芹 张朝明[1] 

机构地区：[1]成都中医药大学附属医院检验科,成都610072 [2]重庆医科大学附属永川医院检验科,重庆402160

出　　处：《检验医学与临床》2016年第15期2073-2074,共2页Laboratory Medicine and Clinic

基　　金：国家自然科学基金资助项目(81273748);成都中医药大学科技基金(ZRQN1424)

摘　　要：目的了解2型糖尿病合并高血压患者血清同型半胱氨酸(HCY)及血管紧张素转换酶(ACE)的水平变化及相关性。方法测定52例单纯2型糖尿病、64例2型糖尿病合并高血压及54例健康体检者(健康对照)的HCY、ACE等指标,并做比较及相关性分析。结果 3组的HCY、ACE、糖化血红蛋白(HbA1c)、空腹血糖(FPG)指标之间差异具有统计学意义(P<0.01),2型糖尿病合并高血压患者的HCY及ACE水平明显高于单纯2型糖尿病患者;2型糖尿病合并高血压患者血清HCY、ACE水平与各指标相关性分析中,HCY与ACE呈显著正相关(r=0.744,P<0.01),且与患者血压控制有关。结论 2型糖尿病血清HCY和ACE水平与合并高血压有关,二者呈高度相关,联合测定对了解2型糖尿病合并高血压病情发展及预后具有一定临床价值。Objective To investigate the relationship between the level of homocysteine （HCY） and angiotensin‐converting en‐zyme （ACE） in patients with type 2 diabetes mellitus and hypertension .Methods The levels of HCY ,ACE ,glycosylated hemoglo‐bin （HbA1c） and fasting plasma glucose（FPG） were detected in 52 patients with purely type 2 diabetes ,64 patients with type 2 dia‐betes mellitus complicated with hypertension and 54 healthy people ,and the indicators were compared between the groups and cor‐relation analysis was also performed .Results There were significant differences of HCY ,ACE ,HbA1c and FPG in three groups （P〈0 .01） .The levels of HCY and ACE in patients with type 2 diabetes mellitus and hypertension were significantly higher than that of inpatients with purely type 2 diabetes .And the level of HCY was positively correlated with ACE in patients with type 2 dia‐betes mellitus and hypertension （r=0 .744 ,P〈0 .01） ,which was related to the control of blood pressure as well .Conclusion The level of serum HCY and ACE in patients with type 2 diabetes mellitus are related to the combination of hypertension ,and these two indicators are highly correlated with each other .The combined detection of the two indicators has a certain clinical value for under‐standing the development and prognosis of the patients with type 2 diabetes mellitus .

关 键 词：2型糖尿病 高血压 同型半胱氨酸 血管紧张素转换酶 

分 类 号：R255.4[医药卫生—中医内科学]