天麻川芎对自发高血压大鼠炎症因子水平的影响  

Effects of Tianma and Chuanxiong on Inflammation Factors in Spontaneous Hypertension Rats

作　　者：付彦君[1] 陈靖[1] 陈莹[1] 

机构地区：[1]辽宁中医药大学,辽宁沈阳110847

出　　处：《中华中医药学刊》2016年第8期2029-2031,共3页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:探索天麻川芎(TC)对自发高血压大鼠炎症因子的影响。方法:自发高血压大鼠(SHR)分为SHR组、卡托普利组(90 mg·kg^(-1)·d^(-1))、TC大剂量组(18.4 g·kg^(-1)·d^(-1))和小剂量组(9.2 g·kg^(-1)·d^(-1)),WKY为正常对照。灌胃给药8周,给药前及给药后每两周测定血压一次。给药结束后,ELISA法测定血浆CRP水平;RT-PCR法测定心肌及主动脉中的TNF-α、IL-6、IL-1βmRNA表达水平。结果:CT小、大剂量组对SHR均无显著降底SHR收缩压作用,但可均可显著降低SHR组的血浆CRP水平(P<0.05)及主动脉及心肌中的TNF-α、IL-6、IL-1βmRNA的表达水平,P<0.05。结论:天麻川芎可降低自发高血压大鼠血浆CRP及主动脉、心肌炎症因子TNF-α、IL-6、IL-1βmRNA的表达水平。Objective： To investigate the effects of Tianma and Chuanxiong on inflammation factors in spontaneous hypertension rats（ SHR）. Methods： SHR were divided into 4 groups： SHR control,captopril（ 90 g·kg-1·d-1）,large dose（ 18. 4 g·kg-1·d-1） and small dose（ 9. 2 g·kg-1·d-1）,WKY were normal control group. Studied medicines were given by i. g. for 8 weeks. 8 weeks later,CRP in plasma were detected by ELISA. The expression of mRNA of TNF-α,IL-6,IL-1βmRNA in cardiac muscle and aorta were detected respectively by RT-PCR. Results： The decline of the expression of mRNA of TNF-α,IL-6,IL-1βmRNA in cardiac muscle and aorta of large and small CT groups was significant. Conclusion： Tianma and Chuanxiong can decrease the levels of CRP in plasma and TNF-α,IL-6 and IL-1βmRNA in cardiac muscle and aorta significantly.

关 键 词：天麻 川芎 自发高血压大鼠(SHR) 炎症因子 

分 类 号：R285.5[医药卫生—中药学]