可溶性髓系细胞触发受体-1在骨科感染患者中的表达及其意义  

Expresses and significance of serum soluble triggering receptor expressed on myeloid cells-1 in patients with infaction of orthopaedics

作　　者：郭永贤[1] 宋世江[1] 周献伟[2] 房中卫 陈云浩[2] 林雪林[1] 

机构地区：[1]泰山医学院附属聊城市第二人民医院骨科,山东临清252600 [2]泰山医学院附属聊城市第二人民医院检验科,山东临清252600

出　　处：《中国当代医药》2016年第21期23-25,共3页China Modern Medicine

基　　金：山东省聊城市卫生和计划委员会科研立项课题(2015214)

摘　　要：目的探讨骨科感染患者血清可溶性髓系细胞触发受体-1（sTREM-1）的浓度变化，为骨科感染的临床诊断提供一种新的客观指标。方法从2015年4月～2016年3月本院患者中选取30例确诊骨科感染者作为感染组．30例健康成年人作为对照组。所有入选者均于清晨采集空腹静脉血。采用ELSIA法测定血清中的sTREM-1浓度，并对结果进行统计学分析。结果感染组的sTREM-1平均浓度较对照组明显升高，差异有统计学意义（P〈0．05）。感染组的阳性率为93．3％，显著高于对照组的10．0％，差异有统计学意义（P〈0．05）。结论血清sTREM-1浓度升高可为骨科感染提供一个新的客观指标，在排除其他感染病灶后，若其浓度较高，提示有感染灶存在，这为抗生素的合理应用提供了证据。Objective To explore the serum concentration change of serum soluble triggering receptor expressed on myeloid cells-1 （sTREM-1） from the orthopaedic infection patients and to find a new objective index for clinical diagnosis.Methods 30 patients with orthopaedic infection from April 2015 to March 2016 in our hospital were selected as the infection group,30 healthy people were selected as the control group.The fasting venous blood was collected in the early morning of all the cases.The serum concentration of sTREM-1 was determined by ELSIA method,and the results were statistically analyzed.Results The average concentration of sTREM-1 in the infection group was higher than that in the control group,with significant difference （P〈0.05）.The positive rate of infection group was 93.3%,which was higher than 10.0% in the control group,with significant difference （P〈0.05）.Conclusions sTREM-1 is a valuable predictor for the early diagnosis of blood stream orthopaedic infection.The rising of the serum concentration of sTREM-1 suggests the presence of infection,excluded other infections,which provides strong evidence to guide the reasonable use of antibiotics.

关 键 词：可溶性髓系细胞触发受体-1 骨科感染 抗生素 

分 类 号：R681.2[医药卫生—骨科学]